Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
First Claim
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1. A monoclonal antibody that recognizes a conformational epitope on human PCSK9 comprising amino acid residues:
- S153, R194, D238, D374, T377, and F379 of SEQ ID NO;
3, wherein the monoclonal antibody reduces binding between PCSK9 and EGFa domain of LDLR.
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Abstract
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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43 Claims
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1. A monoclonal antibody that recognizes a conformational epitope on human PCSK9 comprising amino acid residues:
- S153, R194, D238, D374, T377, and F379 of SEQ ID NO;
3, wherein the monoclonal antibody reduces binding between PCSK9 and EGFa domain of LDLR. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 43)
- S153, R194, D238, D374, T377, and F379 of SEQ ID NO;
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13. A monoclonal antibody that binds to amino acids in human PCSK9 of SEQ ID NO:
- 1, wherein the amino acids comprise S153, R194, D238, D374, T377, and F379 of SEQ ID NO;
3, and wherein the monoclonal antibody reduces binding between PCSK9 and EGFa domain of LDLR. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22)
- 1, wherein the amino acids comprise S153, R194, D238, D374, T377, and F379 of SEQ ID NO;
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23. A monoclonal antibody that recognizes a conformational epitope on human PCSK9, wherein the conformational epitope comprises at least ten of the following residues:
- S153, 1154, P155, R194, D238, A239, 1369, S372, D374, C375, T377, C378, F379, V380, or S381 of SEQ ID NO;
3, wherein the monoclonal antibody reduces binding between PCSK9 and EGFa domain of LDLR. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32)
- S153, 1154, P155, R194, D238, A239, 1369, S372, D374, C375, T377, C378, F379, V380, or S381 of SEQ ID NO;
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33. A monoclonal antibody that binds to amino acids in human PCSK9, wherein the amino acids comprise ten or more of the following amino acids:
- S153, I154, P155, R194, D238, A239, I369, S372, D374, C375, T377, C378, F379, V380, or S381 of SEQ ID NO;
3, and wherein the monoclonal antibody reduces binding between PCSK9 and EGFa domain of LDLR. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42)
- S153, I154, P155, R194, D238, A239, I369, S372, D374, C375, T377, C378, F379, V380, or S381 of SEQ ID NO;
Specification