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Non-fouling polymeric surface modification and signal amplification method for biomolecular detection

  • US 9,493,823 B2
  • Filed: 01/03/2013
  • Issued: 11/15/2016
  • Est. Priority Date: 09/15/2005
  • Status: Active Grant
First Claim
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1. A biomolecular detector, comprising:

  • (a) a substrate having a surface portion;

    (b) a linking layer on said surface portion; and

    (c) a polymer layer formed on said linking layer by a process of surface-initiated polymerization of monomeric units thereon, with each of said monomeric units comprising a monomer core group having at least one protein-resistant head group coupled thereto, to thereby form a brush molecule on said surface portion;

    said brush molecule comprising a stem formed from the polymerization of said monomer core groups, and a plurality of branches formed from said head group projecting from said stem; and

    (d) a first member of a specific binding pair coupled to said brush molecule.

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