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DNA polymerases

  • US 9,493,848 B2
  • Filed: 08/02/2012
  • Issued: 11/15/2016
  • Est. Priority Date: 08/03/2011
  • Status: Active Grant
First Claim
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1. A DNA polymerase mutant comprising SEQ ID NO:

  • 13 with a mutation at position E189 and optionally one or more of the following mutations;

    E230K, E76G, E76K, E76A, E90K, D551N, K206R, Q680R, L552R, H28R, E315K, L30R, L30P, D452N, G504S, G504D, G38R, F73V, H75R, A348V, L351F, A439T, L552R, I553V, D578N, H676R, D732G, E734G, E734K, F749V, E507K, E507A;

    wherein the DNA polymerase mutant exhibits relative to wild-type DNA polymerase of SEQ ID NO;

    13, and under the same conditions, increased polymerase speed, increased affinity to DNA substrate and/or increased resistance to a DNA polymerase inhibitor.

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