Breath analysis system
First Claim
1. A method of detecting fluorescence, the method comprising the steps of:
- (a) inserting an analysis cartridge into an analysis pocket, wherein the analysis cartridge includes a filter assembly that includes a substrate having a carbonyl containing moiety thereon;
(b) rotating the analysis cartridge from a start position to an insertion position,(c) moving the filter assembly within the analysis cartridge from an upper chamber to a fluid chamber that contains an elution solution,(d) rotating the analysis cartridge from the insertion position to an analysis position such that the elution solution drains through the filter assembly and the carbonyl containing moiety is eluted into the elution solution to form a fluorescing solution, and(d) analyzing the fluorescence of the fluorescing solution.
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Accused Products
Abstract
A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with a case, a door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.
95 Citations
17 Claims
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1. A method of detecting fluorescence, the method comprising the steps of:
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(a) inserting an analysis cartridge into an analysis pocket, wherein the analysis cartridge includes a filter assembly that includes a substrate having a carbonyl containing moiety thereon; (b) rotating the analysis cartridge from a start position to an insertion position, (c) moving the filter assembly within the analysis cartridge from an upper chamber to a fluid chamber that contains an elution solution, (d) rotating the analysis cartridge from the insertion position to an analysis position such that the elution solution drains through the filter assembly and the carbonyl containing moiety is eluted into the elution solution to form a fluorescing solution, and (d) analyzing the fluorescence of the fluorescing solution. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method for detecting and quantifying a breath sample, the method comprising the steps of:
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(a) collecting on a first filter assembly a breath sample that includes carbonyl containing moieties, (b) eluting the breath sample with a first elution solution to form a carbonyl containing moieties solution, (c) mixing the carbonyl containing moieties solution with a reactive agent to form a painted solution, (d) capturing on a second filter assembly painted carbonyl containing moieties from the painted solution, (e) eluting the painted carbonyl containing moieties with a second elution solution to form a fluorescing solution, (f) directing light within a predetermined wavelength range through the fluorescing solution, thereby producing a fluorescence, and (g) analyzing the fluorescence. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification