Diffuse optical tomography methods and system for determining optical properties

• US 9,498,134 B1
• Filed: 03/28/2016
• Issued: 11/22/2016
• Est. Priority Date: 03/28/2016
• Status: Active Grant

• Current Assignee: Cephalogics, Llc
• Original Assignee: Cephalogics, Llc
• Inventors: Seshagiri, Chandran V., Hallacoglu, Bertan, Trobaugh, Jason W.
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): HOFFMAN, JOANNE M
• Application Number:
  US15/083,010
• Time in Patent Office: 239 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 2576/026 for the brain
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence

Abstract

Optical source and detector arrangements, systems, and methods are described, which may be used to provide or analyze information about a subject, including hemoglobin and deoxygenated hemoglobin concentrations. Multiple optical detectors can be positioned at different distances from an optical source. The optical sources may irradiate the subject with optical signals and the optical detectors can detect the optical signals from the optical sources after passing through the subject. Analysis of the detected signals source can yield information about the subject.

Claims

1. An apparatus comprising:

a first optical source disposed at a first position and configured to emit a first optical signal of a first wavelength;

an arrangement of optical detectors, at least some of which are positioned at different distances from the first optical source, including a first subset of multiple optical detectors positioned a first distance from the first optical source and a second subset of multiple optical detectors positioned a second distance greater than the first distance from the first optical source, wherein the first subset of multiple optical detectors and the second subset of multiple optical detectors are configured to receive the first optical signal,

wherein a first optical detector of the first subset of multiple optical detectors is configured to produce a first output signal indicative of a first received optical intensity of the first optical signal,

wherein a second optical detector of the second subset of optical detectors is configured to produce a second output signal indicative of a second received optical intensity of the first optical signal, and

wherein a third distance between the first optical detector of the first subset of multiple optical detectors and the second optical detector of the second subset of multiple optical detectors is a smallest distance from among a plurality of distances between the first optical detector and the multiple optical detectors of the second subset; and

a processor coupled to the first and second subsets of multiple optical detectors and configured to receive from the first and second subsets of multiple optical detectors signals detected by those detectors, including the first output signal from the first optical detector and the second output signal from the second optical detector, the processor being further configured to process in combination the first output signal and the second output signal.

2. The apparatus of claim 1, wherein the processor is configured to process in combination the first output signal and the second output signal by determining a difference between the first received optical intensity and the second received optical intensity.

3. The apparatus of claim 1, wherein the processor is coupled to a memory and configured to access from the memory information identifying the plurality of distances between optical detectors of the second subset and the first optical detector.

4. The apparatus of claim 1, wherein the first optical source, the first optical detector, and the second optical detector are not disposed on a same straight line.

5. The apparatus of claim 1, wherein the first optical source and the arrangement of optical detectors are disposed on a flexible substrate to form a flexible array, such that a distance between the first optical source and the first optical detector is dependent on a flexed state of the flexible substrate.

6. The apparatus of claim 1, wherein the first optical source is configured to emit a second optical signal at a second wavelength at a same location as the first wavelength, the first optical detector is configured to produce a third output signal indicative of a third received optical intensity of the second optical signal, and the second optical detector is configured to produce a fourth output signal indicative of a fourth received optical intensity of the second optical signal.

7. The apparatus of claim 6, wherein the processor is further configured to process in combination the first output signal, the second output signal, the third output signal, and the fourth output signal.

8. The apparatus of claim 1, wherein the processor is configured to determine from processing in combination the first output signal and the second output signal, a property of a subject through which the first optical signal passes.

9. The apparatus of claim 8, wherein the property is absolute oxygen saturation.

10. The apparatus of claim 8, wherein the property is absolute total hemoglobin.

11. The apparatus of claim 8, further comprising a display coupled to the processor and configured to display a quantified value of the property.