Methods of conditioning sheet bioprosthetic tissue
First Claim
1. A method for preparing bioprosthetic tissue membrane material, comprising:
- cross-linking a tissue membrane having a fibrous side and a smooth side;
removing material from the fibrous side of the cross-linked tissue membrane to smooth the fibrous side; and
subjecting the cross-linked tissue membrane to a glycerin-based treatment solution.
1 Assignment
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Accused Products
Abstract
Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes.
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Citations
28 Claims
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1. A method for preparing bioprosthetic tissue membrane material, comprising:
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cross-linking a tissue membrane having a fibrous side and a smooth side; removing material from the fibrous side of the cross-linked tissue membrane to smooth the fibrous side; and subjecting the cross-linked tissue membrane to a glycerin-based treatment solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 27)
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9. A method for fabricating a heart valve leaflet, comprising:
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cross-linking a bioprosthetic tissue membrane having opposite sides and a non-uniform thickness; removing material from at least one of the sides of the tissue membrane to smooth a fibrous side of the tissue and to render the thickness more uniform; subjecting the tissue membrane to a glycerin-based treatment solution; and forming a heart valve leaflet from the tissue membrane to have an arcuate cusp edge and a free edge opposite the cusp edge, both of which surround a central region. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 28)
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20. A method for fabricating a heart valve with bioprosthetic tissue leaflets comprising:
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selecting a bioprosthetic tissue membrane having a fibrous side and a smooth side and a non-uniform thickness; cross-linking a bioprosthetic tissue membrane having a fibrous side and a smooth side and a non-uniform thickness; removing material from the fibrous side of the tissue membrane to smooth the fibrous side; subjecting the tissue membrane to a glycerin-based treatment solution; forming at least one heart valve leaflet from the tissue membrane after the glycerin-based treatment solution to have a peripheral edge region, a free edge opposite the peripheral edge region, and a central region surrounded by the peripheral edge region and free edge; and attaching a plurality of the heart valve leaflets to a structural stent by connecting the peripheral edge regions of each leaflet to the structural stent. - View Dependent Claims (21, 22, 23, 24, 25, 26)
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Specification