Compositions and methods for combination ingredient delivery

• US 9,498,435 B2
• Filed: 05/19/2016
• Issued: 11/22/2016
• Est. Priority Date: 02/11/2015
• Status: Active Grant

• Current Assignee: Johnson & Wales University
• Original Assignee: The Fix, LLC
• Inventors: Allio, Michael K., Lane, Stephen, Wo, Marco
• Primary Examiner(s): Arnold, Ernst V
• Assistant Examiner(s): Chang, Kyung Sook
• Application Number:
  US15/159,433
• Publication Number:
  US 20160256383A1
• Time in Patent Office: 187 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A23G 3/563 products with an inedible support, e.g. a stick
• CPC Class Codes: A23L 2/52 Adding ingredients adding preservatives A23L2/44
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/09 having two or more such linkages
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 31/245 Amino benzoic acid types, e.g. procaine, novocaine salicylic acid esters A61K31/60
• CPC Class Codes: A61K 31/29 Antimony or bismuth compounds
• CPC Class Codes: A61K 31/4402 only substituted in position 2, e.g. pheniramine, bisacodyl
• CPC Class Codes: A61K 31/4453 only substituted in position 1, e.g. propipocaine, diperodon
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/616 : by carboxylic acids, e.g. acetylsalicylic acid
• CPC Class Codes: A61K 31/695 : Silicon compounds
• CPC Class Codes: A61K 31/7004 : Monosaccharides having only carbon, hydrogen and oxygen atoms
• CPC Class Codes: A61K 31/7028 : Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
• CPC Class Codes: A61K 31/80 : Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
• CPC Class Codes: A61K 33/10 : Carbonates; Bicarbonates
• CPC Class Codes: A61K 35/644 : Beeswax; Propolis; Royal jelly; Honey
• CPC Class Codes: A61K 36/185 : Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/28 : Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/53 : Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
• CPC Class Codes: A61K 36/59 : Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
• CPC Class Codes: A61K 36/73 : Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
• CPC Class Codes: A61K 36/752 : Citrus, e.g. lime, orange or lemon
• CPC Class Codes: A61K 36/899 : Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
• CPC Class Codes: A61K 36/9066 : Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
• CPC Class Codes: A61K 36/9068 : Zingiber, e.g. garden ginger
• CPC Class Codes: A61K 47/46 : Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
• CPC Class Codes: A61K 9/0056 : Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
• CPC Class Codes: A61K 9/0095 : Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006

Abstract

Described herein are compositions, methods, and devices for relief of a cough, cold, sore throat, or allergy, or a related symptom. Also described herein are compositions, methods, and devices for the prevention, treatment and/or amelioration of a digestive illness or digestive discomfort, or a related symptom of either.

Claims

1. A composition comprising:

a plurality of active pharmaceutical ingredients, wherein the plurality of active pharmaceutical ingredients comprises an analgesic, antihistamine, antitussive, expectorant, nasal decongestant, or demulcent, wherein the plurality of active pharmaceutical ingredients provide relief for a cold, cough, or sore throat, or a related symptom, and wherein the plurality of active pharmaceutical ingredients comprises;

a. aspirin or acetaminophen present in an amount of about 325 to 650 mg;

b. menthol present in an amount of about 5 to 10 mg; and

c. benzocaine present in an amount about 2 to 15 mg; and

a plurality of botanical ingredients, wherein the plurality of botanical ingredients comprises;

a. cooked isomalt present in an amount of about 18000 to 21000 mg;

b. elderberry tincture present in an amount of about 1000 to 1200 mg;

c. honey present in an amount of about 400 to 600 mg;

d. tartaric acid present in an amount of about 30 to 60 mg;

e. marshmallow powder present in an amount of about 30 to 60 mg;

f. lemon oil present in an amount of about 10 to 30 mg;

g. Echinacea extract present in an amount of about 8 to 16 mg;

h. tinofend present in an amount of about 5 to 15 mg;

i. Stevia, 40% present in an amount of about 5 to 15 mg; and

j. Thyme oil present in an amount of about 1 to 10 mg.

11. The composition claim 1, wherein the composition is in the form of a lollipop, lozenge, powder, or liquid.

2. A composition comprising:

a plurality of active pharmaceutical ingredients, wherein the plurality of active pharmaceutical ingredients comprises an analgesic, antihistamine, antitussive, expectorant, nasal decongestant, or demulcent, wherein the plurality of active pharmaceutical ingredients provide relief for a cold, cough, or sore throat, or a related symptom, and wherein the plurality of active pharmaceutical ingredients comprises;

a. aspirin present in an amount of about 70 to 90 mg;

b. menthol present in an amount of about 0.5 to 3 mg; and

c. benzocaine present in an amount about 0.5 to 3 mg; and

a plurality of botanical ingredients, wherein the plurality of botanical ingredients comprises;

a. cooked isomalt present in an amount of about 4000 to 6000 mg;

b. elderberry tincture present in an amount of about 200 to 400 mg;

c. honey present in an amount of about 50 to 300 mg;

d. tartaric acid present in an amount of about 5 to 20 mg;

e. marshmallow powder present in an amount of about 5 to 20 mg;

f. lemon oil present in an amount of about 1 to 10 mg;

g. Echinacea extract present in an amount of about 1 to 10 mg;

h. tinofend present in an amount of about 0.5 to 5 mg;

i. Stevia, 40% present in an amount of about 0.5 to 5 mg; and

j. Thyme oil present in an amount of about 0.5 to 5 mg.

12. The composition claim 2, wherein the composition is in the form of a lollipop, lozenge, powder, or liquid.

3. A composition for cold, cough, or sore throat relief,

wherein the composition is in the form of a lollipop and comprises:

a. aspirin present in an amount of about 325 to 650 mg;

b. menthol present in an amount of about 5 to 10 mg;

c. benzocaine present in an amount about 2 to 15 mg;

d. cooked isomalt present in an amount of about 19974 mg;

e. elderberry tincture present in an amount of about 1100 mg;

f. honey present in an amount of about 440 mg;

g. tartaric acid present in an amount of about 55 mg;

h. marshmallow powder present in an amount of about 40 mg;

i. lemon oil present in an amount of about 20 mg;

j. Echinacea extract present in an amount of about 12 mg;

k. tinofend present in an amount of about 10 mg;

l. Stevia, 40% present in an amount of about 9 mg; and

m. Thyme oil present in an amount of about 4 mg.

4. A composition for cold, cough, or sore throat relief,

wherein the composition is in the form of a lozenge and comprises:

a. aspirin present in an amount of about 81.25 mg;

b. menthol present in an amount of about 1.5 mg;

c. benzocaine present in an amount about 1.25 mg;

d. cooked isomalt present in an amount of about 4993.5 mg;

e. elderberry tincture present in an amount of about 275 mg;

f. honey present in an amount of about 110 mg;

g. tartaric acid present in an amount of about 13.75 mg;

h. marshmallow powder present in an amount of about 10 mg;

i. lemon oil present in an amount of about 5 mg;

j. Echinacea extract present in an amount of about 3 mg;

k. tinofend present in an amount of about 2.5 mg;

l. Stevia, 40% present in an amount of about 2.25 mg; and

m. Thyme oil present in an amount of about 1 mg.

5. A composition comprising:

a plurality of active pharmaceutical ingredients, wherein the plurality of active pharmaceutical ingredient provides for, amelioration or treatment of a disease state associated with a digestive illness, and wherein the plurality of active pharmaceutical ingredients comprises;

a. calcium carbonate present in an amount of about 1000 to 2000 mg; and

b. simethicone present in an amount of about 50 to 200 mg; and

a plurality of botanical ingredients, and wherein the plurality of botanical ingredients is present comprises;

a. honey present in an amount about 5000 to 6000 mg;

b. oats present in an amount about 4000 to 5000 mg;

c. catnip glycerine present in an amount of about 500 to 1000 mg;

d. chamomile flower present in an amount of about 300 to 600 mg;

e. marshmallow powder present in an amount of about 200 to 500 mg;

f. meadowsweet present in an amount of about 200 to 500 mg;

g. ginger powder present in an amount of about 100 to 300 mg; and

h. turmeric present in an amount of about 50 to 150 mg.

6. The composition of claim 5, wherein the composition is in the form of a slurry.

13. The composition of claim 5, further comprising a microstructure which comprises the plurality of active pharmaceutical ingredients or the plurality of botanical ingredients.

7. A composition comprising:

a plurality of active pharmaceutical ingredients, wherein the plurality of active pharmaceutical ingredient provides for, amelioration or treatment of a disease state associated with a digestive illness, and wherein the plurality of active pharmaceutical ingredients comprises;

a. calcium carbonate present in an amount of about 1000 to 2000 mg; and

b. simethicone present in an amount of about 50 to 200 mg; and

a plurality of botanical ingredients, and wherein the plurality of botanical ingredients is present comprises;

a. honey present in an amount about 4000 to 5000 mg;

b. meadowsweet present in an amount of about 2500 to 3500 mg;

c. chamomile present in an amount of about 1500 to 2000 mg;

d. lemon balm present in an amount of about 2000 to 3500 mg; and

f. turmeric present in an amount of about 400 to 600 mg.

8. The composition of claim 7, wherein the composition is in a carbonated or creamy form.

14. The composition of claim 7, further comprising a microstructure which comprises the plurality of active pharmaceutical ingredients or the plurality of botanical ingredients.

9. A composition for digestive relief, comprising:

a plurality of active pharmaceutical ingredients, wherein the plurality of active pharmaceutical ingredients comprises an antacid, antidiarrheal, antiemetic, antiflatulent, stomach acidifier, or overindulgence reliever; and

a plurality of botanical ingredients, wherein the plurality of botanical ingredients comprises cooked isomalt, elderberry tincture, honey, tartaric acid, marshmallow powder, lemon oil, Echinacea extract, tinofend, stevia, and thyme oil, and wherein the plurality of active pharmaceutical ingredients and the plurality of botanical ingredients are present in a ratio by weight of about 1;

5 to 1;

11.

10. The composition of claim 9, wherein the plurality of active pharmaceutical ingredients and the plurality of botanical ingredients are present in a ratio by weight of 1:

7.5.

15. The composition of claim 9, further comprising a microstructure which comprises the plurality of active pharmaceutical ingredients or the plurality of botanical ingredients.

16. The composition of claim 9, wherein the composition is in a carbonated or creamy form.

17. The composition of claim 9, wherein:

the antacid is calcium carbonate or bismuth subsalicylate;

the antidiarrheal is alumina powder, bismuth subsalicylate, calcium gluconate, calcium polycarbophil, carboxymethylcellulose sodium, charcoal, glycine, homatropine methylbromide, hyocyamine sulfate, kaolin, lactobacillus acidophilus, lactobacillus bulgaricus, loperamine HCl, opium powder, opium tincture, paregoric, pectin, phenyl salicylate, psyllium husk, polycarbophil, potassium carbonate, scopolamine hydrobromide, sodium carboxymethylcellulose, or zinc phenolsulfonate;

the antiemetic is dimenhydrinate or meclizine hydrochloride;

the antiflatulent is simethicone;

the stomach acidifier is glutamic acid hydrochloride;

or

the overindulgence reliever is acetaminophen, aluminum hydroxide, aluminum hydroxide gel, aspirin, bismuth subsalicylate, caffeine, fructose, magnesium carbonate, magnesium trisilicate, sodium citrate in solution, or sodium acetylsalicylate.

18. The composition of claim 17, wherein the plurality of botanical ingredients enhances the activity of at least one of the active pharmaceutical ingredients to provide relief for a digestive illness associated with a food allergy, food sensitivity, celiac disease, irritable bowel syndrome (IBS), overindulgence in food or alcohol, gastroesophageal reflux disease (GERD), ulcerative colitis, Crohn'"'"'s disease, bacterial infection, parasitic infection, or viral infection.