Medical articles having therapeutic-agent-containing regions formed from coalesced polymer particles

• US 9,498,563 B2
• Filed: 04/23/2004
• Issued: 11/22/2016
• Est. Priority Date: 04/23/2004
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Schwarz, Marlene C., Richard, Robert E., Zhong, Sheng-Ping
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): MILLER, CHERYL L
• Application Number:
  US10/830,950
• Publication Number:
  US 20050239508A1
• Time in Patent Office: 4,596 Days
• Field of Search: 623 139- 148, 427/2.24, 427/2.25
• US Class Current: 1/1
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

Medical articles, such as drug-releasing patches or implantable or insertable medical devices, which are made up of a medical article substrate and a therapeutic-agent-containing region. The therapeutic-agent-containing region is made up of (i) a water-dispersible therapeutic agent and (ii) coalesced polymer particles supplied by an aqueous dispersion. Also described are methods of forming such medical articles, and methods of releasing a therapeutic agent within a patient using such medical articles.

Claims

1. A medical article comprising:

a medical article substrate; and

a coating layer disposed over the medical article substrate;

wherein the coating layer comprises;

(i) a water-dispersible therapeutic agent that is not an antimicrobial agent; and

(ii) coalesced polymer particles of a block copolymer comprising a poly(alkylene) chain and a poly(vinyl aromatic) chain, the coalesced polymer particles formed by providing an aqueous dispersion of polymer particles having a weight average diameter ranging from 0.001 microns to 10 microns and coalescing the polymer particles to form the coalesced polymer particles, the block copolymer rendered dispersible in the aqueous dispersion via inclusion of charged hydrophilic groups;

wherein the medical article is configured to release the therapeutic agent once the medical article has been administered to a patient.

2. The medical article of claim 1, wherein the charged hydrophilic groups are selected from neutralized carboxylic acid groups and sulfonate groups.

3. The medical article of claim 1, wherein the coalesced polymer particles are formed from an aqueous dispersion of polymer particles having a weight average diameter ranging from 0.01 microns to 1 micron.

4. A medical article comprising:

a medical article substrate; and

a coating layer disposed over the medical article substrate;

wherein the coating layer comprises;

(i) a water-dispersible therapeutic agent that is not an antimicrobial agent; and

(ii) coalesced polymer particles of a sulfonated polystyrene-polyisobutylene block copolymer that were coalesced from an aqueous dispersion of polystyrene-polyisobutylene polymer particles having a weight average diameter ranging from 0.001 microns to 10 microns;

wherein the medical article is configured to release the therapeutic agent once the medical article has been administered to a patient.

5. The medical article of claim 4, wherein the coalesced polymer particles are formed from an aqueous dispersion of polymer particles having a weight average diameter ranging from 0.01 microns to 1 micron.