Substituted cyclopentanes for inducing hair growth

• US 9,499,478 B2
• Filed: 09/16/2014
• Issued: 11/22/2016
• Est. Priority Date: 02/14/2011
• Status: Active Grant

• Current Assignee: Allergan Incorporated (Abbvie Incorporated)
• Original Assignee: Allergan Incorporated (Abbvie Incorporated)
• Inventors: Woodward, David F., Wang, Jenny W., Poloso, Neil J., Gac, Todd S., Burk, Robert M., Garst, Michael E.
• Primary Examiner(s): Willis, Douglas M
• Application Number:
  US14/488,093
• Publication Number:
  US 20150005377A1
• Time in Patent Office: 798 Days
• Field of Search: 560/121, 568/838
• US Class Current: 1/1
• CPC Class Codes: A61K 8/42 Amides
• CPC Class Codes: A61P 17/14 for baldness or alopecia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61Q 7/00 Preparations for affecting hair growth
• CPC Class Codes: C07C 235/34 having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
• CPC Class Codes: C07C 2601/08 the ring being saturated
• CPC Class Codes: C07C 405/00 Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
• CPC Class Codes: C07C 405/0041 containing nitrogen

Abstract

Provided herein, inter alia, are, methods of using esters of bimatoprost with the Formula (I):

Claims

1. A method for inducing hair growth in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):

2. The method of claim 1, wherein said administering is topical administering.

3. The method of claim 2, wherein said administering is topical epidermal administering.

4. The method of claim 1, wherein said subject suffers from alopecia.

5. The method of claim 1, wherein said subject is in need of hair growth of the cilia, the supercilia, scalp pili, or body pili.

6. The method of claim 1, wherein said compound is of Formula (IIIb)

7. The method of claim 1, wherein said compound is of Formula (IVa)

8. The method of claim 1, wherein said compound is of Formula (IVb)