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Methods and compositions for treating Huntington's disease

  • US 9,499,597 B2
  • Filed: 07/29/2014
  • Issued: 11/22/2016
  • Est. Priority Date: 02/29/2012
  • Status: Active Grant
First Claim
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1. A non-naturally occurring zinc finger protein consisting of 4, 5 or 6 zinc finger domains ordered F1 to F4, F1 to F5 or F1 to F6, respectively, wherein the zinc finger protein binds to an Htt gene and comprises one- or two-finger domains at positions F2 or F2 and F3, the two-finger domains comprising the recognition helix regions sequences in F2 and F3 as shown in a single row of Table 2C and the one-finger domain of F2 comprising MACCRYA (SEQ ID NO:

  • 175);

    RSANLRE (SEQ ID NO;

         176);

    RNADRKK (SEQ ID NO;

    177);

    RSDVLSE SEQ ID NO;

    42);

    RSAVLSE (SEQ ID NO;

    148);

    QSGDLTR (SEQ ID NO;

    18);

    QNATRIK (SEQ ID NO;

    178) or QSSDLSR (SEQ ID NO;

    31).

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