Method for in vivo expansion of T regulatory cells
First Claim
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1. A method of delaying acute rejection of a transplanted allograft in a subject, the method comprising the step of administering to the subject, prior to the subject receiving the transplanted allograft, a sufficient amount of a tumor necrosis factor receptor superfamily member 25 (TNFRSF25) agonist to increase the frequency of thymically-derived, natural T regulatory cells (nTreg) and for delaying rejection of the transplanted allograft, wherein the agonist is selected from the group consisting of:
- an agonistic anti-TNFRSF25 antibody and a soluble form of TL1A.
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Abstract
Compositions specific for TNF-receptor superfamily member 25 (TNFRSF25, DR3) modulate the immune response by regulating T regulatory cells.
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15 Claims
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1. A method of delaying acute rejection of a transplanted allograft in a subject, the method comprising the step of administering to the subject, prior to the subject receiving the transplanted allograft, a sufficient amount of a tumor necrosis factor receptor superfamily member 25 (TNFRSF25) agonist to increase the frequency of thymically-derived, natural T regulatory cells (nTreg) and for delaying rejection of the transplanted allograft, wherein the agonist is selected from the group consisting of:
- an agonistic anti-TNFRSF25 antibody and a soluble form of TL1A.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 10. A method of delaying acute rejection of a transplanted allograft in a subject, the method comprising administering to the subject a sufficient amount of a TNFRSF25 agonist to delay rejection of the transplanted allograft, wherein the TNFRSF25 agonist is a soluble form of TL1A.
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