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Cell free DNA diagnostic testing standards

  • US 9,499,870 B2
  • Filed: 09/26/2014
  • Issued: 11/22/2016
  • Est. Priority Date: 09/27/2013
  • Status: Active Grant
First Claim
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1. A cell-free nucleic acid diagnostic proficiency testing standard composition for analyzing non-invasive prenatal genetic tests, comprisinga set of at least two nucleosomal nucleic acid preparations,wherein the nucleosomal nucleic acid preparations in the set have a quantity of a first nucleosomal nucleic acid preparation from a first cell line derived from a first individual and a quantity of a second nucleosomal nucleic acid preparation from a second cell line derived from a second individual,wherein the first individual is a mother or father of the second individual and the first and second individuals have different copy numbers of at least one chromosome,and wherein the quantity of the second nucleosomal nucleic acid preparation as a percentage of the quantity of the first nucleosomal nucleic acid preparation plus the quantity of the second nucleosomal nucleic acid preparation is different for each of the nucleosomal nucleic acid preparations in the set.

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