System and method for measuring fluidics in arteries

• US 9,504,443 B2
• Filed: 07/01/2015
• Issued: 11/29/2016
• Est. Priority Date: 07/08/2014
• Status: Active Grant

• Current Assignee: Nadarasa Visveshwara
• Original Assignee: Nadarasa Visveshwara
• Inventors: Visveshwara, Nadarasa
• Primary Examiner(s): Peng, Bo J
• Application Number:
  US14/789,137
• Publication Number:
  US 20160007953A1
• Time in Patent Office: 517 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2503/045 Newborns, e.g. premature baby monitoring
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/150038 for blood from umbilical cord
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/065 to determine blood output from the heart in general A61B5/029
• CPC Class Codes: A61B 8/0866 involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby
• CPC Class Codes: A61B 8/0891 for diagnosis of blood vessels
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4416 related to combined acquisition of different diagnostic modalities, e.g. combination of ultrasound and X-ray acquisitions
• CPC Class Codes: A61B 8/445 Details of catheter construction
• CPC Class Codes: A61B 8/4477 using several separate ultrasound transducers or probes
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: A61B 8/5223 for extracting a diagnostic or physiological parameter from medical diagnostic data for algorithms to analyse biomedical images G06T7/0012

Abstract

An apparatus for performing measurements in an artery includes a Doppler catheter, comprising a Doppler transducer and a wire connected to the Doppler transducer; and an elongated catheter body having a conduit therein for housing the wire of the Doppler catheter. The body has a proximal end and a distal end; wherein the wire is movable in the conduit relative to the catheter body so that the Doppler transducer and the wire are capable of being threaded into said conduit at the proximal end after the distal end of the catheter has been inserted into the artery, until the Doppler transducer emerges outside the conduit at the distal end of said body for performing ultrasound measurements in the artery. Another embodiment employs at least an additional side transducer for measuring the cross-sectional dimension of the artery useful for computing blood flow.

Claims

1. A method for measuring blood velocity and derived indices related to blood velocity in an umbilical artery of a neonatal patient, comprising:

inserting into the umbilical artery an elongated catheter body having a proximal end and a distal end so that the distal end is located at a desired location in the umbilical artery for measuring the blood velocity, said elongated catheter body defining a conduit therein, said desired location being close to a patent ductus arteriosus of the neonatal patient;

positioning an end of a Doppler catheter near the proximal end of the elongated catheter body, wherein the Doppler catheter includes a Doppler transducer, a wire connected to the Doppler transducer, and a sleeve that provides a sealed environment for the Doppler transducer and the wire when the Doppler transducer and/or the wire is in a first position outside the conduit, when the Doppler transducer is in a second position at said desired location, and when the Doppler transducer is in a position between the first position and the second position;

thereafter inserting into the conduit, at the proximal end of the elongated catheter body, the Doppler transducer and the wire so that the Doppler transducer passes through, and extends outside, the conduit at the distal end, to be located at said desired location, thereby folding the sleeve;

performing continuously ultrasound measurement of the blood velocity in the umbilical artery at said desired location using the Doppler transducer to measure antegrade and retrograde blood velocity in the umbilical artery; and

continuously displaying, in real time, information related to the blood velocity in the umbilical artery.

2. The method of claim 1, further comprising performing blood pressure measurement in the umbilical artery when the ultrasound measurement of the blood using the Doppler transducer is performed.

3. The method of claim 2, further comprising displaying information related to the ultrasound measurement of the blood and information related to the blood pressure measurement at substantially the same time.

4. The method of claim 1, further comprising infusing a substance to the umbilical artery or retrieving a blood sample from the umbilical artery, when the ultrasound measurement of the blood using the Doppler transducer is performed.

5. The method of claim 1, further comprising infusing a substance to the umbilical artery, retrieving a blood sample from the artery, or performing blood pressure measurement in the umbilical artery, when the Doppler transducer and the wire are not in the conduit.

6. The method of claim 1, further comprising conveying ultrasound measurement signals from the Doppler transducer through said wire to an instrument for analysis and display of the signals, wherein the display includes information about systolic time intervals.

7. The method of claim 1, said Doppler catheter further comprising a second transducer and a second wire connected to the second transducer and said method further comprising measuring at least one cross-sectional dimension of the umbilical artery using said second transducer.

8. The method of claim 7, further comprising deriving a blood flow value from measurements of the Doppler transducer and said at least one cross-sectional dimension of the umbilical artery.

9. The method of claim 7, wherein at least two cross-sectional dimensions of the umbilical artery are measured.

10. The method of claim 9, wherein at least two cross-sectional dimensions of the umbilical artery are measured at two different angular orientations of the Doppler transducer relative to the umbilical artery.

11. The method of claim 9, further comprising computing parameters related to blood in arteries, said parameters including a systolic time interval parameter, from a result of measurements of the Doppler transducer.

12. The method of claim 1, said Doppler catheter including a first connector, said method further comprising connecting a second connector attached to the elongated catheter body to the first connector to form a stable connection, wherein the inserting of the Doppler transducer and wire threads the Doppler transducer and a portion of the wire through said conduit and said stable connection until the Doppler transducer emerges at said desired location and outside the conduit at the distal end of said body.

13. A method for measuring blood velocity in an artery, comprising:

inserting into the artery an elongated catheter body having a proximal end and a distal end so that the distal end is located at a desired location in the artery for measuring the blood velocity, said elongated catheter body defining a conduit therein;

positioning an end of a Doppler catheter near the proximal end of the elongated catheter body, wherein the Doppler catheter includes a Doppler transducer, a wire connected to the Doppler transducer, and a sleeve that provides a sealed environment for the Doppler transducer and the wire when the Doppler transducer and/or the wire is in a first position outside the conduit, when the Doppler transducer is in a second position at said desired location, and when the Doppler transducer is in a position between the first position and the second position;

thereafter inserting into the conduit, at the proximal end of the elongated catheter body, the Doppler transducer and the wire so that the Doppler transducer passes through, and extends outside, the conduit at the distal end, to be located at said desired location, thereby folding the sleeve;

performing continuously ultrasound measurement of the blood velocity in the artery at said desired location using the Doppler transducer; and

continuously displaying, in real time, information related to blood velocity in the artery and systolic time intervals.

14. The method of claim 13, wherein the artery is an umbilical artery of a neonatal patient, said location being close to a patent ductus arteriosus of the neonatal patient, and the ultrasound measurement measures antegrade and retrograde blood velocity.

15. The method of claim 13, wherein the inserting inserts the elongated catheter body into a radial, pulmonary, femoral or an umbilical artery.

16. The method of claim 13, said Doppler catheter further comprising a second transducer and a second wire connected to the second transducer and said method further comprising measuring at least one cross-sectional dimension of the artery using said second transducer.

17. A method for performing measurements in an artery, comprising:

inserting into the artery an elongated catheter body having a proximal end and a distal end so that the distal end is located at a desired location in the artery for measuring blood velocity, said elongated catheter body defining a conduit therein;

positioning an end of a Doppler catheter near the proximal end of the elongated catheter body, wherein the Doppler catheter includes a Doppler transducer, a wire connected to the Doppler transducer, and a sleeve that provides a sealed environment for the Doppler transducer and the wire when the Doppler transducer and/or the wire is in a first position outside the conduit, when the Doppler transducer is in a second position at said desired location, and when the Doppler transducer is in a position between the first position and the second position;

thereafter inserting into the conduit at the proximal end of the elongated catheter body, the Doppler transducer, a second transducer, wires connected to the Doppler transducer and the second transducer and a first connector so that the Doppler and the second transducers pass through and extend outside the conduit at the distal end, to be located at said desired location, thereby folding the sleeve; and

performing ultrasound measurement of the blood velocity in the artery and a dimension of the artery at said desired location using the Doppler transducer and the second transducer.

18. The method of claim 17, said Doppler catheter including a first connector, said method further comprising connecting a second connector attached to the elongated catheter body to the first connector to form a stable connection, wherein the inserting of the Doppler transducer and wires threads the Doppler transducer and the second transducer and a portion of the wire through said conduit and said stable connection until the Doppler transducer and the second transducer emerge at said desired location and outside the conduit at the distal end of said elongated catheter body.

19. The method of claim 18, wherein the artery is an umbilical artery of a neonatal patient, said location being close to a patent ductus arteriosus of the patient, and the ultrasound measurement measures antegrade and retrograde blood velocity.

20. The method of claim 18, wherein the inserting inserts the catheter body into a radial, pulmonary, femoral or an umbilical artery.