Methods and compositions for treating bacterial infection

• US 9,504,688 B2
• Filed: 05/02/2013
• Issued: 11/29/2016
• Est. Priority Date: 05/02/2012
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Michigan (University of Michigan)
• Original Assignee: Board of Regents of the University of Michigan (University of Michigan), Curators of the University of Missouri (University of Missouri)
• Inventors: Ginsburg, David, Larsen, Scott D., Yestrepsky, Bryan, Sun, Hongmin
• Primary Examiner(s): Leeser, Erich A
• Application Number:
  US14/397,798
• Publication Number:
  US 20150132352A1
• Time in Patent Office: 1,307 Days
• US Class Current: 1/1
• CPC Class Codes: A01N 43/54 1,3-Diazines; Hydrogenated 1,3-diazines
• CPC Class Codes: A01N 43/84 six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
• CPC Class Codes: A01N 43/90 having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/517 ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
• CPC Class Codes: A61K 31/5377 not condensed and containing further heterocyclic rings, e.g. timolol
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/02 Local antiseptics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C07D 239/56 One oxygen atom and one sulfur atom
• CPC Class Codes: C07D 239/70 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 471/10 Spiro-condensed systems
• CPC Class Codes: C07D 487/10 Spiro-condensed systems
• CPC Class Codes: C07D 491/107 with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections (e.g., biofilms).

Claims

1. A pharmaceutical composition, comprising:

a compound selected from the group consisting of a)

2. The composition of claim 1, wherein said compound is selected from the group consisting of:

3. The composition of claim 1, further comprising a pharmaceutically acceptable carrier.

4. The composition of claim 1, wherein said composition inhibits growth or biological activity of S. aureus and/or S. epidermidis.

5. The composition of claim 1, wherein said composition inhibits biofilm formation by S. aureus and/or S. epidermidis.

6. The composition of claim 4, wherein said S. aureus and/or S. epidermidis are in a biofilm.

7. The composition of claim 1, wherein said composition further comprises a known antibiotic compound.

12. A surface coated in a compound of claim 1.

13. The surface of claim 12, wherein said surface is a surface of a medical device.

8. A method of inhibiting the growth or biological activity of S. aureus and/or S. epidermidis, comprising contacting said S. aureus and/or S. epidermidis with a compound having the structure of Formula I, II, III or IV

9. The method of claim 8, wherein said S. aureus and/or S. epidermidis are present in a biofilm.

10. The method of claim 9, wherein said compound prevents biofilm formation by said S. aureus and/or S. epidermidis.

11. The method of claim 8, further comprising the step of contacting said S. aureus and/or S. epidermidis with a known antibiotic compound.