Systems, devices and methods for the treatment of neurological disorders and conditions

• US 9,504,827 B2
• Filed: 05/26/2015
• Issued: 11/29/2016
• Est. Priority Date: 10/05/2009
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: DeGiorgio, Christopher M., Miller, Patrick
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US14/721,300
• Publication Number:
  US 20160106979A1
• Time in Patent Office: 553 Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0476 Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/0504 Subcutaneous electrodes
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36075 Headache or migraine
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36096 Mood disorders, e.g. depression, anxiety or panic disorder
• CPC Class Codes: A61N 1/3616 Voltage density or current density
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle

Abstract

The present disclosure relates to methods, devices, and systems used for the treatment of and/or promoting recovery from various neurological disorders and conditions, including epilepsy and other seizure disorders and movement and other related disorders; for promoting recovery from acute or chronic brain injury (e.g. stroke, hypoxia/ischemia, head trauma, subarachnoid hemorrhage, and other forms of brain injury, for awakening and/or promoting the recovery of patients in various levels of coma, altered mental status or vegetative state); or for promoting recovery from chronic daily headache and migraine and related disorders via external (cutaneous) stimulation of the sensory branches of the trigeminal nerve in the face and forehead. More specifically, devices and electrode assemblies configured for stimulation of the supraorbital, supratrochlear, infraorbital, auriculotemporal, zygomaticotemporal, zygomaticoorbital, zygomaticofacial, nasal and infratrochlear nerves are disclosed.

Claims

1. A system for trigeminal nerve stimulation for treatment of a neurological disorder or condition, the system comprising:

a pulse generator; and

a cutaneous electrode assembly in electrical communication with the pulse generator, the assembly comprising;

a first electrode comprising at least one contact configured for cutaneous placement over an ophthalmic nerve on one side of a patient'"'"'s forehead;

a second electrode comprising at least one contact configured for cutaneous placement over an ophthalmic nerve on an opposing side of the patient'"'"'s forehead; and

an insulating region surrounding each of the first and second electrodes.

2. A method for treating a neurological disorder or condition by trigeminal nerve stimulation, comprising:

aligning a cutaneous electrode assembly with the nasal midline of a patient, wherein the cutaneous electrode assembly includes a first contact separated from a second contact by an expected separation between the ophthalmic nerves on the patient'"'"'s forehead;

applying the aligned cutaneous electrode assembly on the patient'"'"'s forehead such that the first contact overlays a first one of the ophthalmic nerves and the second contact overlays a remaining second one of the ophthalmic nerves on the patient'"'"'s forehead; and

driving electrical signals through the applied cutaneous electrode assembly to treat the neurological disorder or condition.