Autonomic modulation using transient response with intermittent neural stimulation
First Claim
1. A method comprising:
- using a neural stimulator system to deliver neural stimulation therapy, whereinthe neural stimulation therapy includes a plurality of neural stimulation bursts,each neural stimulation burst includes a plurality of neural stimulation pulses, andsuccessive neural stimulation bursts are separated by a time without neural stimulation pulses;
evaluating, using the neural stimulator system, an evoked response to the neural stimulation bursts of the neural stimulation therapy, wherein evaluating the evoked response includes;
sensing the evoked response to the neural stimulation bursts, wherein sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts; and
performing a statistical analysis of the evoked response to the plurality of neural stimulation bursts to determine if the neural stimulation bursts provide a desired evoked response for the neural stimulation therapy; and
performing an action using the neural stimulation system including;
changing neural stimulation parameters for the neural stimulation therapy if the evoked response does not provide the desired evoked response, orrecording results of the statistical analysis for access by a clinician.
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Abstract
In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
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Citations
20 Claims
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1. A method comprising:
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using a neural stimulator system to deliver neural stimulation therapy, wherein the neural stimulation therapy includes a plurality of neural stimulation bursts, each neural stimulation burst includes a plurality of neural stimulation pulses, and successive neural stimulation bursts are separated by a time without neural stimulation pulses; evaluating, using the neural stimulator system, an evoked response to the neural stimulation bursts of the neural stimulation therapy, wherein evaluating the evoked response includes; sensing the evoked response to the neural stimulation bursts, wherein sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts; and performing a statistical analysis of the evoked response to the plurality of neural stimulation bursts to determine if the neural stimulation bursts provide a desired evoked response for the neural stimulation therapy; and performing an action using the neural stimulation system including; changing neural stimulation parameters for the neural stimulation therapy if the evoked response does not provide the desired evoked response, or recording results of the statistical analysis for access by a clinician. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system, comprising:
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a neural stimulator configured to generate stimulation energy to stimulate the autonomic neural target; a memory with a programmed neural stimulation therapy stored therein, wherein the therapy includes a plurality of programmable neural stimulation parameters for use in controlling a dose of the neural stimulation therapy, wherein the neural stimulation therapy includes a plurality of neural stimulation bursts, each burst includes a plurality of neural stimulation pulses, and successive bursts are separated by a time without neural stimulation pulses; a controller configured to communicate with the memory and the neural stimulator to control the neural stimulation therapy using the programmable parameters; a sensor adapted to sense at least one physiological parameter affected by the neural stimulation bursts and indicative of an evoked response to the neural stimulation therapy; and a response extractor configured to receive a time series of parameter data from the sensor and to extract evoked response data from the time series of parameter data and configured to perform a statistical analysis of the evoked response data to the plurality of neural stimulation bursts to determine if the neural stimulation bursts provide a desired evoked response for the neural stimulation therapy, wherein the device is configured to perform an action including; changing neural stimulation parameters for the neural stimulation therapy if the evoked response does not provide the desired evoked response;
orrecording results of the statistical analysis for access by a clinician. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification