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Methods and compositions for specific modulation of MCL-1

  • US 9,505,816 B2
  • Filed: 05/15/2015
  • Issued: 11/29/2016
  • Est. Priority Date: 12/09/2008
  • Status: Active Grant
First Claim
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1. A peptide comprising an amino acid sequence selected from the group consisting of:

  • LEVESATQLRXFGDXLNFRQKL (SEQ ID NO;

         63),LEVESXTQLXRFGDKLNFRQL (SEQ ID NO;

         64),LEVESXTQLXRFGDKLNF (SEQ ID NO;

         65),LEVXSATXLRRFGDKLNFRQKL (SEQ ID NO;

         66),LEVESATQLRRFGDKLXFRQXL (SEQ ID NO;

         67), andLEVEXATQXRRFGDKLNFRQKL (SEQ ID NO;

         68),wherein X is a non-natural amino acid containing an olefinic side chain, andwherein the peptide comprises a stabilized alpha-helix with the non-natural amino acids connected by a hydrocarbon staple.

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