Polymer comprising a plurality of phenothiazine groups and methods of making the same

• US 9,505,884 B2
• Filed: 12/09/2015
• Issued: 11/29/2016
• Est. Priority Date: 05/28/2010
• Status: Active Grant

• Current Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Original Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Inventors: Fei, Jiangfeng, Chiang, William, Kerrigan, Frank, Green, Stuart, Robson, Craig, Easterfield, Howard
• Primary Examiner(s): Truong, Duc
• Application Number:
  US14/963,908
• Publication Number:
  US 20160083519A1
• Time in Patent Office: 356 Days
• Field of Search: 528/419, 528/377, 544/37, 424/91
• US Class Current: 1/1
• CPC Class Codes: A61K 49/0004 Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
• CPC Class Codes: C07D 279/08 condensed with carbocyclic rings or ring systems
• CPC Class Codes: C07D 279/20 with hydrogen atoms directly attached to the ring nitrogen atom
• CPC Class Codes: C07D 417/14 containing three or more hetero rings
• CPC Class Codes: C08F 8/30 Introducing nitrogen atoms or nitrogen-containing groups
• CPC Class Codes: C08F 8/34 Introducing sulfur atoms or sulfur-containing groups
• CPC Class Codes: C08G 59/4007 Curing agents not provided for by the groups C08G59/42 - C08G59/66
• CPC Class Codes: C08G 59/4064 sulfur containing compounds C08G59/4021, C08G59/4028 take precedence
• CPC Class Codes: C08G 73/024 Polyamines containing oxygen in the form of ether bonds in the main chain
• CPC Class Codes: C08G 75/24 Polysulfonates
• CPC Class Codes: C12Q 1/004 mediator-assisted
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52

Abstract

A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V):

and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.

Claims

1. A polymer comprising the general formula (VIII):

2. The polymer of claim 1, wherein the sum of x and y is from 10 to 10,000.

3. The polymer of claim 2, wherein the sum of x and y is from 20 to 1,000.

4. The polymer of claim 1, wherein x and y independently are an integer from 1 to 70.

5. The polymer of claim 4, wherein x and y independently are an integer from 2 to 20.

6. The polymer of claim 4, wherein x and y independently are an integer from 10 to 30.

7. The polymer of claim 1, wherein m is 1 and R′

is an aliphatic group.

8. The polymer of claim 7, wherein R′

is an alkyl group having from 1 to 10 carbons atoms.

9. The polymer of claim 7, wherein R′

is an aryl group.

10. An electrochemical test sensor including a mediator, the mediator including a polymer comprising the general formula (VIII):

11. The test sensor of claim 10, wherein the sum of x and y is from 10 to 10,000.

12. The test sensor of claim 11, wherein the sum of x and y is from 20 to 1,000.

13. The test sensor of claim 10, wherein x and y independently are an integer from 1 to 70.

14. The test sensor of claim 13, wherein x and y independently are an integer from 2 to 20.

15. The test sensor of claim 13, wherein x and y independently are an integer from 10 to 30.

16. The test sensor of claim 10, wherein m is 1 and R′

is an aliphatic group.

17. The test sensor of claim 16, wherein R′

is an alky group having from 1 to 10 carbons atoms.

18. The test sensor of claim 16, wherein R′

is an alkyl group.

19. The test sensor of claim 10 further including glucose oxidase.

20. The test sensor of claim 10 further including glucose dehydrogenase.