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Modifications for antisense compounds

  • US 9,506,057 B2
  • Filed: 02/25/2013
  • Issued: 11/29/2016
  • Est. Priority Date: 03/26/2010
  • Status: Active Grant
First Claim
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1. An antisense oligonucleotide comprising at least one modification that is incorporated at the terminal end or between two nucleotides of the antisense oligonucleotide, wherein the modification increases binding affinity and nuclease resistance of the antisense oligonucleotide, and wherein the modification is a napthyl-azo compound.

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