Spectroscopic analysis of nutrient materials for use in a cell culture process
First Claim
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1. A method of evaluating a nutrient material, the method comprising:
- performing a Raman spectroscopic analysis on a sample of the nutrient material to obtain a Raman spectrum; and
identifying a value of a quality parameter based on the Raman spectrum, the quality parameter relating to the nutrient material or to a cell culture grown using the nutrient material, wherein the quality parameter is a Day 8 pH or a Peak 5 or a Lactate Production Integral.
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Abstract
In some embodiments, aspects of the disclosure relate to methods of evaluating cell culture materials, for example, nutrient materials, or other materials that can be used in cell culture media.
16 Citations
14 Claims
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1. A method of evaluating a nutrient material, the method comprising:
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performing a Raman spectroscopic analysis on a sample of the nutrient material to obtain a Raman spectrum; and identifying a value of a quality parameter based on the Raman spectrum, the quality parameter relating to the nutrient material or to a cell culture grown using the nutrient material, wherein the quality parameter is a Day 8 pH or a Peak 5 or a Lactate Production Integral. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of evaluating a nutrient material, the method comprising:
performing a Raman spectroscopic analysis on a sample of the nutrient material to obtain a Raman spectrum; and
identifying a value of a quality parameter based on the Raman spectrum, the quality parameter relating to the nutrient material or to a cell culture grown using the nutrient material, wherein the quality parameter is a Day 8 pH.
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13. A method of evaluating a nutrient material, the method comprising:
- performing a Raman spectroscopic analysis on a sample of the nutrient material to obtain a Raman spectrum; and
identifying a value of a quality parameter based on the Raman spectrum, the quality parameter relating to the nutrient material or to a cell culture grown using the nutrient material, wherein the quality parameter is a Peak 5.
- performing a Raman spectroscopic analysis on a sample of the nutrient material to obtain a Raman spectrum; and
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14. A method of evaluating a nutrient material, the method comprising:
- performing a Raman spectroscopic analysis on a sample of the nutrient material to obtain a Raman spectrum; and
identifying a value of a quality parameter based on the Raman spectrum, the quality parameter relating to the nutrient material or to a cell culture grown using the nutrient material, wherein the quality parameter is a Lactate Production Integral.
- performing a Raman spectroscopic analysis on a sample of the nutrient material to obtain a Raman spectrum; and
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