Biosensor and biosensor manufacturing method

• US 9,506,889 B2
• Filed: 10/07/2014
• Issued: 11/29/2016
• Est. Priority Date: 07/12/2010
• Status: Active Grant

• Current Assignee: ARKRAY, Inc
• Original Assignee: ARKRAY, Inc
• Inventors: Matsuura, Yoshimitsu, Kanda, Shuzo
• Primary Examiner(s): Sines, Brian J
• Application Number:
  US14/508,872
• Publication Number:
  US 20150041338A1
• Time in Patent Office: 784 Days
• Field of Search: 422/50, 422/68.1, 422/502, 422/503, 422/504, 422/420, 422/425, 422/430, 422/82.01, 422/507, 422/412, 435/283.1, 435/287.1, 435/287.7, 435/287.14, 600/300, 600/309, 600/316, 600/347, 600/365, 436/43, 436/180
• US Class Current: 1/1
• CPC Class Codes: B01L 2300/08 Geometry, shape and general structure
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/161 Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: G01N 2021/0346 Capillary cells; Microcells
• CPC Class Codes: G01N 2035/00108 Test strips, e.g. paper
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/44743 Introducing samples
• CPC Class Codes: Y10T 156/1052 with cutting, punching, tearing or severing
• CPC Class Codes: Y10T 436/25 including sample preparation

Abstract

A biosensor manufacturing method including a sheet material forming process and a dicing process. In the sheet material forming process a sheet material with plural biosensor forming sections is formed. Each of the biosensor forming sections includes a first base plate, a second base plate stacked on the first base plate and forming a capillary between the second base plate and the leading end portion of the first base plate for sucking in sample liquid, and a hydrophilic layer formed on the second base plate at least in a region facing the capillary. In the dicing process plural biosensors are obtained by dicing the sheet material with a blade from the first base plate side at the leading end of each of the biosensor forming sections, such that the leading end of the capillary opens onto the leading end face of the first base plate and the second base plate.

Claims

1. A biosensor comprising:

a first base plate having a leading end portion;

a second base plate having a leading end portion, said second base plate stacked on the first base plate and forming a capillary between the leading end portion of the second base plate and the leading end portion of the first base plate that is for sucking in a sample liquid;

a hydrophilic layer formed on the second base plate at least in a region facing the capillary; and

wherein a region on the first base plate facing the capillary has either a test reagent or an electrode present; and

wherein said second base plate has a projecting portion formed on the leading end portion thereof, said projecting portion extends out from the second base plate away from the capillary in a direction perpendicular to the second base plate.

2. The biosensor of claim 1, wherein the first base plate is formed with higher toughness than the second base plate.

3. The biosensor of claim 1, wherein the leading end side of the capillary has a cross-section dimension, in the direction of stacking the first base plate and the second base plate, which gets wider on progression toward the leading end.

4. The biosensor of claim 1, wherein the leading end face of the first base plate is formed as a face sloping toward a rear end side of the first base plate on progression way from the second base plate.

5. The biosensor of claim 1, wherein the leading end face of the first base plate is disposed further to a rear end side of the second base plate than a leading end face of the second base plate.

6. The biosensor of claim 1, wherein a region of the first base plate facing the capillary is also provided with a hydrophilic layer.

7. A biosensor sample liquid sucking method in which a sample liquid is sucked in by the biosensor of claim 1, the biosensor sample liquid sucking method comprising:

spotting a sample liquid onto a leading end side of the capillary, such that the sample liquid is caused to creep along a face of the second base plate on a side facing the first base plate, and also caused to creep along a face of the first base plate on a side facing the second base plate.