Physical vapor deposited biosensor components

• US 9,506,890 B2
• Filed: 05/28/2015
• Issued: 11/29/2016
• Est. Priority Date: 12/16/2014
• Status: Active Grant

• Current Assignee: Eastman Chemical Company
• Original Assignee: Eastman Chemical Company
• Inventors: Sambandam, Senthil, Hochstetler, Spencer Erich, Ashford, Dennis L.
• Primary Examiner(s): Van, Luan
• Assistant Examiner(s): ROSENWALD, STEVEN ERIC
• Application Number:
  US14/724,563
• Publication Number:
  US 20160169827A1
• Time in Patent Office: 551 Days
• US Class Current: 1/1
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: C23C 14/22 characterised by the process of coating
• CPC Class Codes: C23C 14/34 Sputtering
• CPC Class Codes: G01N 27/00 Investigating or analysing materials by the use of electric, electrochemical, or magnetic means G01N3/00 – G01N25/00 take precedence; measurement or testing of electric or magnetic variables or of electric or magnetic properties of materials G01R
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 33/5438 Electrodes
• CPC Class Codes: G01N 33/553 Metal or metal coated

Abstract

A biosensor component is provided that provides enhanced characteristics for use in biosensors, such as blood glucose sensors. The biosensor component comprises a substrate and a conductive layer coated on the substrate. The conductive layer includes nickel and chromium, such that a combined weight percent of the nickel and chromium in the conductive layer is in the range of 50 to 99 weight percent.

Claims

1. A biosensor component for use in analyzing a biological sample, said biosensor component comprising:

a substrate;

a conductive layer coated on said substrate; and

a biological reactant for electrochemically reacting with said biological sample,

wherein said conductive layer comprises nickel, chromium, iron, and molybdenum,

wherein a combined weight percent of the nickel and chromium in the conductive layer is in the range of 50 to 98 weight percent,

wherein the weight percent of iron in the conductive layer is at least 2 weight percent, and

wherein the weight percent of molybdenum in the conductive layer is in the range of 2 to 20 weight percent.

2. The biosensor component according to claim 1, wherein said biosensor component comprises an electrode.

3. The biosensor component according to claim 2, wherein said electrode is a working electrode or a reference electrode.

4. The biosensor component according to claim 1, wherein the biosensor is a blood glucose sensor.

5. The biosensor component according to claim 1, wherein said biosensor component comprises a test-strip.

6. The biosensor component according to claim 1, wherein said substrate has a thickness between 25 and 500 μ

m and said conductive layer has a thickness between 15 and 200 nm.

7. The biosensor component according to claim 1, wherein said conductive layer is physical vapor deposited on said substrate.

8. The biosensor component according to claim 1, wherein said conductive layer meets the compositional criteria of one or more of Compositions A3-A6 set forth in Table 1.

9. The biosensor component according to claim 1, wherein said substrate comprises a flexible, non-conductive film.

10. The biosensor component according to claim 1, wherein said substrate comprise polyethylene terephthalate (PET).

11. The biosensor component according to claim 1, wherein said biosensor component has a visible light transmission of no more than 20%.

12. The biosensor component according to claim 1, wherein said biosensor component has a sheet resistance of no more than 100 ohms per square.

13. The biosensor component according to claim 1, wherein the weight percent of nickel in the conductive layer is at least 50 weight percent, wherein the weight percent of chromium in the conductive layer is at least 15 weight percent, wherein the weight percent of iron in the conductive layer is at least 2 weight percent, and wherein the weight percent of molybdenum is at least 7 weight percent and not more than 17 weight percent.

14. The biosensor component according to claim 1, wherein a combined weight percent of the nickel and chromium in the conductive layer is in the range of 50 to 94 weight percent, wherein the weight percent of nickel in the conductive layer is at least 55 weight percent and not more than 60 weight percent, wherein the weight percent of chromium in the conductive layer is at least 15 weight percent and not more than 34 weight percent, wherein the weight percent of iron in the conductive layer is at least 2 weight percent and not more than 5 weight percent, wherein the weight percent of molybdenum in the conductive layer is at least 7 weight percent and not more than 17 weight percent.

15. The biosensor component of claim 1, wherein the biological reactant is an enzyme, a cofactor, or an enzyme-cofactor complex.

16. The biosensor component of claim 1, wherein the biological reactant comprises an enzyme.

17. The biosensor component of claim 1, wherein the biological sample comprises blood and the biological reactant reacts with glucose in the blood.

18. The biosensor component of claim 1, wherein the conductive layer comprises from 7 up to 17 weight percent molybdenum and up to 0.1 weight percent carbon.

19. The biosensor component of claim 1, wherein the conductive layer is constructed of a single layer of an alloy comprising nickel, chromium, iron, and, optionally, carbon components, wherein the single layer exhibits no distinct boundary between the components of the alloy.

20. A biosensor component for use in analyzing a biological sample, said biosensor component comprising:

a substrate;

a conductive layer coated on said substrate; and

a biological reactant for electrochemically reacting with said biological sample,

wherein said conductive layer comprises nickel, chromium, iron, and molybdenum,

wherein the weight percent of nickel in the conductive layer is in the range of 30 to 95 percent,

wherein the weight percent of chromium in the conductive layer is in the range of 0.5 to 60 weight percent,

wherein the weight percent of iron in the conductive layer is in the range of 0.25 to 6 weight percent,

wherein the weight percent of molybdenum in the conductive layer is in the range of 2 to 20 weight percent,

wherein a combined weight percent of the nickel and chromium in the conductive layer is at least 50 weight percent.

21. The biosensor component according to claim 20, wherein the weight percent of nickel in the conductive layer is at least 50 weight percent, wherein the weight percent of chromium in the conductive layer is at least 15 weight percent, wherein the weight percent of iron in the conductive layer is at least 2 weight percent and not more than 6 weight percent.

22. The biosensor component according to claim 21, wherein the combined weight percent of the nickel and chromium in the conductive layer is at least 73 weight percent.

23. The biosensor component according to claim 20, wherein the weight percent of nickel in the conductive layer is at least 55 weight percent and not more than 60 weight percent.

24. The biosensor component according to claim 20, wherein the weight percent of chromium in the conductive layer is at least 15 weight percent and not more than 35 weight percent.

25. The biosensor component according to claim 20, wherein the weight percent of iron in the conductive layer is at least 0.25 weight percent and not more than 5 weight percent.

26. The biosensor component according to claim 20, wherein the weight percent of nickel in the conductive layer is at least 55 weight percent and not more than 60 weight percent, wherein the weight percent of chromium in the conductive layer is at least 15 weight percent and not more than 35 weight percent, wherein the weight percent of iron in the conductive layer is at least 2 weight percent and not more than 5 weight percent, wherein the weight percent of carbon in the conductive layer is 0-0.1 weight percent.

27. The biosensor component according to claim 26, wherein a combined weight percent of the nickel and chromium in the conductive layer is at least 73 weight percent.

28. The biosensor component according to claim 20, wherein said substrate has a thickness between 25 and 500 μ

m and said conductive layer has a thickness between 15 and 200 nm, wherein said substrate comprises a flexible, non-conductive film, wherein said biosensor component has a visible light transmission of no more than 20%, wherein said biosensor component has a sheet resistance of no more than 100 ohms per square.

29. The electrode of claim 20, wherein the biological reactant is an enzyme, a cofactor, or an enzyme-cofactor complex.

30. A biosensor component for use in analyzing a biological sample, said biosensor component comprising:

a substrate;

a conductive layer coated on said substrate; and

at least one of i) an enzyme, ii) a cofactor, and iii) an enzyme-cofactor complex,

wherein said conductive layer comprises nickel, chromium, iron, and molybdenum,

wherein a combined weight percent of the nickel and chromium in the conductive layer is in the range of 50 to 98 weight percent,

wherein the weight percent of iron in the conductive layer is at least 2 weight percent, and

wherein the weight percent of molybdenum in the conductive layer is in the range of 2 to 20 weight percent.

31. The biosensor component of claim 30, wherein the biological sample is blood and the enzyme, cofactor, or enzyme-cofactor complex reacts with glucose in the blood.