Ionic silicone hydrogels
First Claim
1. A silicone hydrogel contact lens formed from a reaction mixture comprisingabout 37 to about 75 wt % of a mixture of slow-reacting hydrophilic monomers, each having a slow-reacting hydrophilic monomer kinetic half life;
- said mixture of slow reacting hydrophilic monomers comprising and at least one slow-reacting ionic monomer;
at least one silicone-containing component having a silicone-containing component kinetic half life, which may be optionally substituted with at least one hydroxyl containing group; and
at least one hydroxyl-containing component selected from said silicone-containing components substituted with at least one hydroxyl containing group, at least one hydroxyalkyl monomer, and mixtures thereof,wherein ratio of each of said slow-reacting hydrophilic component half lives to said silicone-containing component half life is at least 2, and said contact lens uptakes at least about 30 μ
g, of lysozyme from a 2 mg/ml lysozyme solution over 72 hours incubation at 35°
C.
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Abstract
The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature.
73 Citations
66 Claims
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1. A silicone hydrogel contact lens formed from a reaction mixture comprising
about 37 to about 75 wt % of a mixture of slow-reacting hydrophilic monomers, each having a slow-reacting hydrophilic monomer kinetic half life; - said mixture of slow reacting hydrophilic monomers comprising and at least one slow-reacting ionic monomer;
at least one silicone-containing component having a silicone-containing component kinetic half life, which may be optionally substituted with at least one hydroxyl containing group; and at least one hydroxyl-containing component selected from said silicone-containing components substituted with at least one hydroxyl containing group, at least one hydroxyalkyl monomer, and mixtures thereof, wherein ratio of each of said slow-reacting hydrophilic component half lives to said silicone-containing component half life is at least 2, and said contact lens uptakes at least about 30 μ
g, of lysozyme from a 2 mg/ml lysozyme solution over 72 hours incubation at 35°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66)
- said mixture of slow reacting hydrophilic monomers comprising and at least one slow-reacting ionic monomer;
Specification