Apparatus, systems and methods for measuring blood pressure within at least one vessel

• US 9,510,758 B2
• Filed: 10/27/2011
• Issued: 12/06/2016
• Est. Priority Date: 10/27/2010
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Warger, William C. II, Schlachter, Simon C., Gardecki, Joseph, Bouma, Brett Eugene, Tearney, Guillermo J.
• Primary Examiner(s): Cattungal, Sanjay
• Application Number:
  US13/283,143
• Publication Number:
  US 20120108956A1
• Time in Patent Office: 1,867 Days
• Field of Search: 600407-480
• US Class Current: 1/1
• CPC Class Codes: A61B 2576/00 Medical imaging apparatus involving image processing or analysis A61B1/00009, A61B6/52 and A61B8/52 take precedence; image processing per se G06T; details of algorithms for analysing medical images G06T7/0012
• CPC Class Codes: A61B 3/14 Arrangements specially adapted for eye photography apparatus or arrangements for taking photographs per se G03B
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/12 Audiometering
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/202 Assessing bladder functions, e.g. incontinence assessment
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/407 Evaluating the spinal cord A61B5/4896 takes precedence
• CPC Class Codes: A61B 5/42 Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems A61B1/00, A61B5/4857, A61B5/486, A61B5/4866, A61B5/4869 take precedence

Abstract

Exemplary apparatus and method for obtaining information for at least one structure can be provided. For example, it is possible to forward at least one first electro-magnetic radiation to the at least one structure which is external from the apparatus. At least one second electro magnetic radiation provided from the at least one structure (which is based on the first electro-magnetic radiation(s)) can be detected. It is also possible to determine at least one characteristic of the structure(s) based on the second electro-magnetic radiation(s), and obtain data relating to a pressure of at least one portion of the structure(s) based on the characteristic(s).

Claims

1. An apparatus for obtaining information for at least one anatomical structure, comprising:

at least one radiation providing first arrangement configured to forward at least one first electro-magnetic radiation to and impact the at least one anatomical structure which is external from the apparatus;

at least one detector second arrangement configured to detect at least one second electro-magnetic radiation provided from at least one portion within the at least one anatomical structure which is based on the at least one first electro-magnetic radiation; and

at least one computer third arrangement configured to (i) determine at least one characteristic of the at least one anatomical structure based on the at least one second electro-magnetic radiation, and (ii) obtain data relating to a pressure of the at least one portion of the at least one anatomical structure based on the at least one characteristic,

wherein the at least one characteristic is a speckle pattern of the at least one portion.

2. The apparatus according to claim 1, wherein the at least one characteristic includes at least one of (i) a refractive index of the at least one structure, or (ii) a change of the refractive index.

3. The apparatus according to claim 1, wherein the at least one third arrangement is further configured to measure a temperature of the at least one portion.

4. The apparatus according to claim 1, wherein the anatomical structure includes a blood vessel.

5. The apparatus according to claim 4, wherein the pressure is provided within the blood vessel.

6. The apparatus according to claim 4, wherein the at least one characteristic relates to a structure of at least one red blood cell of the at least one portion.

7. The apparatus according to claim 1, wherein the anatomical structure includes a fascial compartment.

8. The apparatus according to claim 7, wherein the pressure is provided within the fascial compartment.

9. The apparatus according to claim 1, wherein the at least one first arrangement is further configured to forward at least one third electro-magnetic radiation to a reference, and wherein the at least one second arrangement is configured to detect the at least one second electro-magnetic radiation provided from the at least one structure and interfered with at least one fourth radiation provided from the reference which is associated with the at least one third electro-magnetic radiation.

10. The apparatus according to claim 9, wherein the first and second arrangements form at least one of (i) low coherence interferometric system, (ii) optical frequency domain imaging system, or (iii) spectral domain optical coherence tomography system.

11. The apparatus according to claim 9, wherein the at least one characteristic includes at least one of (i) a phase of the at least one second electromagnetic radiation relative to the at least one fourth electromagnetic radiation, or (ii) a change of the phase.

12. The apparatus according to claim 9, wherein the at least one third arrangement is further configured to measure a temperature of the at least one portion, wherein the at least one third arrangement obtains the data relating to the pressure using the temperature and the at least one characteristic.

13. The apparatus according to claim 1, wherein the at least one first electro-magnetic radiation is a light radiation.

14. The apparatus according to claim 1, wherein the at least one second electromagnetic radiation is a plurality of distinct radiation provided from (i) different spatial locations on the at least one structure, or (ii) different temporal locations from the at least one structure.

15. The apparatus according to claim 1, wherein the at least one characteristic includes at least one of (i) a refractive index of the at least one structure, or (ii) a change of the refractive index.

16. The apparatus according to claim 1, wherein the at least one second arrangement detects the at least one second electromagnetic radiation based on a wavelength thereof or an angle of remittance from the at least one structure relative to an angle of incidence of the at least one first electromagnetic radiation on the at least one structure.

17. The apparatus according to claim 1, wherein the anatomical structure includes at least one of (i) an eye, (ii) an ear, (iii) a brain compartment, (iv) a spinal canal, (v) an airway, (vi) a heart cavity, (vii) a gastro-intestinal organ, or (viii) a bladder.

18. The apparatus according to claim 1, wherein the at least one characteristic includes at least one of (i) a phase of the at least one second electromagnetic radiation relative to the at least one first electromagnetic radiation, or (ii) a change of the phase.

19. An apparatus for obtaining information for at least one anatomical structure, comprising:

at least one radiation providing first arrangement configured to forward at least one first electro-magnetic radiation to and impact the at least one anatomical structure which is external from the apparatus;

at least one detector second arrangement configured to detect at least one second electro-magnetic radiation provided from at least one portion within the at least one anatomical structure which is based on the at least one first electro-magnetic radiation; and

at least one computer third arrangement configured to (i) determine at least one characteristic of the at least one anatomical structure based on the at least one second electro-magnetic radiation, and (ii) obtain data relating to a pressure of the at least one portion of the at least one anatomical structure based on the at least one characteristic,

wherein the at least one third arrangement is further configured to measure a temperature of the at least one portion, and

wherein the at least one third arrangement obtains the data relating to the pressure using the temperature and the at least one characteristic.

20. An apparatus for obtaining information for at least one anatomical structure, comprising:

at least one radiation providing first arrangement configured to forward at least one first electro-magnetic radiation to and impact the at least one anatomical structure which is external from the apparatus;

at least one detector second arrangement configured to detect at least one second electro-magnetic radiation provided from at least one portion within the at least one anatomical structure which is based on the at least one first electro-magnetic radiation; and

at least one computer third arrangement configured to (i) determine at least one characteristic of the at least one anatomical structure based on the at least one second electro-magnetic radiation, and (ii) obtain data relating to a pressure of the at least one portion of the at least one anatomical structure based on the at least one characteristic,

wherein the at least one characteristic further includes a refractive index that is determined based on a speckle pattern of the at least one portion.

21. The apparatus according to claim 20, wherein the at least one third arrangement correlates the speckle pattern with further speckle patterns obtained at different wavelengths or times from the at least one portion.

22. A method for obtaining information for at least one anatomical structure which is performed by an apparatus, comprising:

forwarding at least one first electro-magnetic radiation to and impacting the at least one anatomical structure which is external from the apparatus;

detecting at least one second electro-magnetic radiation provided from at least one portion within the at least one anatomical structure which is based on the at least one first electro-magnetic radiation;

determining at least one characteristic of the at least one anatomical structure based on the at least one second electro-magnetic radiation; and

obtaining data relating to a pressure of at least one portion of the at least one anatomical structure based on the at least one characteristic,

wherein the at least one characteristic is a speckle pattern of the at least one portion.

23. The according to claim 22, further comprising:

forwarding at least one third electro-magnetic radiation to a reference;

interfering the at least one second electro-magnetic radiation provided from the at least one structure with at least one fourth radiation provided from the reference, the second and fourth electro-magnetic radiations being based on the first and third electro-magnetic radiations, respectively.

24. The method according to claim 23, further comprising measuring a temperature of the at least one portion, wherein the obtaining of the data relating to the pressure is performed using the temperature and the at least one characteristic.

25. A method for obtaining information for at least one anatomical structure which is performed by an apparatus, comprising:

forwarding at least one first electro-magnetic radiation to and impacting the at least one anatomical structure which is external from the apparatus;

detecting at least one second electro-magnetic radiation provided from at least one portion within the at least one anatomical structure which is based on the at least one first electro-magnetic radiation;

determining at least one characteristic of the at least one anatomical structure based on the at least one second electro-magnetic radiation;

obtaining data relating to a pressure of at least one portion of the at least one anatomical structure based on the at least one characteristic; and

measuring a temperature of the at least one portion, wherein the obtaining of the data relating to the pressure is performed using the temperature and the at least one characteristic.

26. A method for obtaining information for at least one anatomical structure which is performed by an apparatus, comprising:

forwarding at least one first electro-magnetic radiation to and impacting the at least one anatomical structure which is external from the apparatus;

detecting at least one second electro-magnetic radiation provided from at least one portion within the at least one anatomical structure which is based on the at least one first electro-magnetic radiation;

determining at least one characteristic of the at least one anatomical structure based on the at least one second electro-magnetic radiation; and

obtaining data relating to a pressure of at least one portion of the at least one anatomical structure based on the at least one characteristic,

wherein the at least one characteristic further includes a refractive index that is determined based on a speckle pattern of the at least one portion.