Pulse wave propagation time measurement device

• US 9,510,759 B2
• Filed: 06/25/2015
• Issued: 12/06/2016
• Est. Priority Date: 02/26/2013
• Status: Active Grant

• Current Assignee: Murata Manufacturing Co Limited
• Original Assignee: Murata Manufacturing Co Limited
• Inventors: Hayashi, Takanori, Shimuta, Toru
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US14/750,260
• Publication Number:
  US 20150366473A1
• Time in Patent Office: 530 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02416 using photoplethysmograph signals, e.g. generated by infrared radiation A61B5/14552 takes precedence
• CPC Class Codes: A61B 5/0245 by using sensing means generating electric signals, i.e. ECG signals
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/352 Detecting R peaks, e.g. for synchronising diagnostic apparatus; Estimating R-R interval
• CPC Class Codes: A61B 5/7289 Retrospective gating, i.e. associating measured signals or images with a physiological event after the actual measurement or image acquisition, e.g. by simultaneously recording an additional physiological signal during the measurement or image acquisition

Abstract

A pulse wave propagation time measurement device including a first signal processor section that filters an electrocardiographic signal detected by an electrocardiographic sensor, a second signal processor section that filters a photoelectric pulse wave signal detected by a photoelectric pulse wave sensor, peak detectors respectively that detect peaks of the electrocardiographic signal and the photoelectric pulse wave signal, delay time obtaining sections respectively that obtain a delay time of the electrocardiographic signal and of the photoelectric pulse wave signal, peak correctors respectively that correct the peaks of the electrocardiographic signal and the photoelectric pulse wave signal based on the delay time of the electrocardiographic signal and the photoelectric pulse wave signal, and a pulse wave propagation time measurement section that obtains a pulse wave propagation time from a time difference between the corrected peaks of the electrocardiographic signal and the photoelectric pulse wave signal.

Claims

1. A pulse wave propagation time measurement device comprising:

an electrocardiographic sensor including at least one electrocardiographic electrode configured to detect an electrocardiographic signal;

a photoelectric pulse wave sensor including a light-emitting element and a light-receiving element configured to detect a photoelectric pulse wave signal;

a first signal processor configured to filter the electrocardiographic signal;

a second signal processor configured to filter the photoelectric pulse wave signal;

a peak detector configured to detect a peak of the electrocardiographic signal filtered by the first signal processor and a peak of the photoelectric pulse wave signal filtered by the second signal processor;

a delay time obtaining unit configured to obtain a delay time of at least one of the electrocardiographic signal filtered by the first signal processor and the photoelectric pulse wave signal filtered by the second signal processor;

a correcting unit configured to correct at least one of the peak of the electrocardiographic signal and the peak of the photoelectric pulse wave signal detected by the peak detector based on at least one of the delay time of the electrocardiographic signal and the photoelectric pulse wave signal obtained by the delay time obtaining unit; and

a calculating unit configured to calculate a pulse wave propagation time from a time difference between the peak of the photoelectric pulse wave signal and the peak of the electrocardiographic signal corrected by the correcting unit.

2. The pulse wave propagation time measurement device according to claim 1, wherein the delay time obtaining unit is configured to obtain the delay time of the electrocardiographic signal and the photoelectric pulse wave signal based on frequency components of the electrocardiographic signal and the photoelectric pulse wave signal, respectively.

3. The pulse wave propagation time measurement device according to claim 2, wherein the frequency components correspond to a pulse rate obtained from the photoelectric pulse wave signal or a heart rate obtained from the electrocardiographic signal.

4. The pulse wave propagation time measurement device according to claim 1, further comprising an inverting circuit configured to invert polarity of the electrocardiographic signal detected by the electrocardiographic sensor.

5. The pulse wave propagation time measurement device according to claim 1, wherein, when a plurality of peaks of the electrocardiographic signal have different polarities, the calculating unit calculates a peak that forms a longest pulse wave propagation time within a predetermined time as a true peak among the plurality of peaks of the electrocardiographic signal.

6. The pulse wave propagation time measurement device according to claim 1, wherein the calculating unit determines that the calculated pulse wave propagation time is in error when the calculated pulse wave propagation time is not within a predetermined time.

7. The pulse wave propagation time measurement device according to claim 1, wherein, when the calculated pulse wave propagation time is not within a predetermined time, the calculating unit determines the detected peak of the electrocardiographic signal is in error when a change rate of a heartbeat interval is larger than a change rate of a pulse interval.

8. The pulse wave propagation time measurement device according to claim 1, wherein, when the calculated pulse wave propagation time is not within a predetermined time, the calculating unit determines the detected peak of the photoelectric pulse wave signal is in error when a change rate of the pulse interval is larger than a change rate of the heartbeat interval.

9. The pulse wave propagation time measurement device according to claim 1, wherein, when the calculated pulse wave propagation time is not within a predetermined time, the calculating unit:

searches for a combination of an electrocardiographic signal peak and a photoelectric pulse wave signal peak from the detected peak and one or more additional peaks of the electrocardiographic signal, and the detected peak and one or more additional peaks of the photoelectric pulse wave signal peaks that allows a pulse wave propagation time to fall within the predetermined time,

selects the combination based on at least one of a rate of change of the pulse wave propagation time, amplitude of the electrocardiographic signal peak and rate of change of the amplitude, amplitude of the photoelectric pulse wave signal peak and a rate of change of the amplitude, a rate of change rate of the heartbeat interval, and a rate of change rate of the pulse interval; and

calculates the pulse wave propagation time based on the selecting combination.

10. A method for determining a pulse wave propagation time, the method comprising:

detecting, by an electrocardiographic sensor, an electrocardiographic signal;

detecting, by a photoelectric pulse wave sensor, a photoelectric pulse wave signal;

filtering by at least one signal processor, the electrocardiographic signal and the photoelectric pulse wave signal;

detecting a peak of the electrocardiographic signal and a peak of the photoelectric pulse wave signal;

obtaining a delay time of at least one of the electrocardiographic signal and the photoelectric pulse wave signal;

correcting at least one of the peak of the electrocardiographic signal and the peak of photoelectric pulse wave signal based on at least one of the delay time of the electrocardiographic signal and the delay time of the photoelectric pulse wave signal, respectively; and

calculating a pulse wave propagation time from a time difference between the peak of the photoelectric pulse wave signal and the peak of the electrocardiographic signal.

11. The method of determining pulse wave propagation time according to claim 10, further comprising obtaining the delay time of the electrocardiographic signal and the delay time of the photoelectric pulse wave signal based on frequency components of the electrocardiographic signal and the photoelectric pulse wave signal, respectively.

12. The method of determining pulse wave propagation time according to claim 11, wherein the frequency components correspond to a pulse rate obtained from the photoelectric pulse wave signal or a heart rate obtained from the electrocardiographic signal.

13. The method of determining pulse wave propagation time according to claim 10, further comprising inverting a polarity of the detected electrocardiographic signal.

14. The method of determining pulse wave propagation time according to claim 10, further comprising calculating a peak that forms a longest pulse wave propagation time within a predetermined time as a true peak among a plurality of peaks of the electrocardiographic signal when the plurality of peaks of the electrocardiographic signal have different polarities.

15. The method of determining pulse wave propagation time according to claim 10, further comprising determining that the calculated pulse wave propagation time is in error when the calculated pulse wave propagation time is not within a predetermined time.

16. The method of determining pulse wave propagation time according to claim 10, wherein, when the calculated pulse wave propagation time is not within a predetermined time, the method further comprises determining the detected peak of the electrocardiographic signal is in error when a change rate of a heartbeat interval is larger than a change rate of a pulse interval.

17. The method of determining pulse wave propagation time according to claim 10, wherein, when the calculated pulse wave propagation time is not within a predetermined time, the method further comprises determining the detected peak of the photoelectric pulse wave signal is in error when a change rate of the pulse interval is larger than a change rate of the heartbeat interval.

18. The method of determining pulse wave propagation time according to claim 10, wherein, when the calculated pulse wave propagation time is not within a predetermined time, the method further comprises:

searching for a combination of an electrocardiographic signal peak and a photoelectric pulse wave signal peak from the detected peak and one or more additional peaks of the electrocardiographic signal, and the detected peak and one or more additional peaks of the photoelectric pulse wave signal peaks that allows a pulse wave propagation time to fall within the predetermined time,

selecting the combination based on at least one of a rate of change of the pulse wave propagation time, amplitude of the electrocardiographic signal peak and rate of change of the amplitude, amplitude of the photoelectric pulse wave signal peak and a rate of change of the amplitude, a rate of change rate of the heartbeat interval, and a rate of change rate of the pulse interval; and

calculating the pulse wave propagation time based on the selecting combination.

19. A pulse wave propagation time measurement device comprising:

an electrocardiographic sensor including at least one electrocardiographic electrode configured to detect an electrocardiographic signal;

a photoelectric pulse wave sensor including a light-emitting element and a light-receiving element configured to detect a photoelectric pulse wave signal;

a plurality of filters configured to filter the electrocardiographic signal and the photoelectric pulse wave signal, respectively; and

at least one hardware processor configured to;

detect a peak of the electrocardiographic signal filtered by the first signal processor and a peak of the photoelectric pulse wave signal filtered by the second signal processor,

obtain a delay time of at least one of the electrocardiographic signal filtered by the first signal processor and the photoelectric pulse wave signal filtered by the second signal processor,

correct at least one of the peak of the electrocardiographic signal and the peak of the photoelectric pulse wave signal detected by the peak detector based on at least one of the delay time of the electrocardiographic signal and the delay time of the photoelectric pulse wave signal, and

calculate a pulse wave propagation time from a time difference between the peak of the photoelectric pulse wave signal and the peak of the electrocardiographic signal corrected by the correcting unit.

20. The pulse wave propagation time measurement device according to claim 19, wherein, when the calculated pulse wave propagation time is not within a predetermined time, the at least one hardware processor is further configured to determines the detected peak of the electrocardiographic signal is in error when:

a change rate of a heartbeat interval is larger than a change rate of a pulse interval, or

a change rate of the pulse interval is larger than a change rate of the heartbeat interval.