Impedance based anatomy generation

• US 9,510,769 B2
• Filed: 04/23/2014
• Issued: 12/06/2016
• Est. Priority Date: 05/08/2009
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Rhythmia Medical, Inc. (Boston Scientific Corporation)
• Inventors: Harlev, Doron, Csendes, Alpar, Badics, Zsolt
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US14/259,384
• Publication Number:
  US 20140235986A1
• Time in Patent Office: 958 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0044 for the heart
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/0537 Measuring body composition by impedance, e.g. tissue hydration or fat content
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/283 Invasive
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/6858 with a distal basket, e.g. expandable basket
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 8/0883 for diagnosis of the heart

Abstract

Methods and systems for the determination and representation of anatomy anatomical information are disclosed herein.

Claims

1. A method comprising:

inserting a catheter into a heart, the catheter comprising multiple, spatially distributed electrodes including multiple sets of electrodes each set comprising at least two electrodes;

for each of the multiple different sets of electrodes, causing current to flow between at least some of the electrodes and in response to current flow, measuring an electrical signal at each of one or more measuring electrodes; and

determining anatomical information about the heart by detecting a boundary of the heart based at least in part on impedance information generated based on the measured signals, wherein;

the anatomical information accounts for a change in conductivity at the cardiac chamber boundary with a first conductivity inside the cardiac chamber boundary and a second conductivity outside the cardiac chamber boundary, the first conductivity being different from the second conductivity; and

the anatomical information comprises a representation of at least a portion of a boundary of the heart.

2. The method of claim 1, wherein the impedance information is based on at least one of a conductivity or permittivity contrast between blood and surrounding tissue.

3. The method of claim 1, wherein the impedance information comprises complex impedance information based on both a permittivity contrast and a conductivity contrast between blood and surrounding tissue.

4. The method of claim 2, wherein detecting the boundary of the heart comprises determining a closed and parameterized surface around at least a portion of the catheter based on the measured signals, the surface representing a surface at which the conductivity value changes.

5. The method of claim 4, wherein the surface provides a boundary between a region represented by the first conductivity inside the surface and a region represented by the second conductivity outside the surface.

6. The method of claim 4, wherein determining the anatomical information further comprises, for each of the determined surfaces selecting one or more regions of the surface corresponding to an expected boundary of the heart based at least in part on a distance between a portion of the surface and the catheter and joining the regions of the determined surfaces corresponding to an expected chamber boundary to generate the anatomical information.

7. The method of claim 6, wherein selecting the one or more regions comprises selecting the one or more regions based at least in part on a magnitude of a distortion field, the distortion field being based at least in part on a difference between a field calculated based on the measurements and a field in a homogonous medium.

8. The method of claim 6, wherein selecting the one or more regions comprises selecting the one or more regions based at least in part on an error calculation in an optimization used to generate the surface.

9. The method of claim 1, further comprising:

using the multiple electrodes on the catheter to measure cardiac signals at the catheter electrodes in response to electrical activity in the heart; and

determining physiological information at multiple locations of the boundary of the heart based on positions of the catheter electrodes and the measured cardiac signals.

10. The method of claim 1, further comprising displaying at least a portion of the anatomical information.

11. A system comprising:

a catheter comprising multiple, spatially distributed electrodes including multiple sets of electrodes each set comprising at least two electrodes, the electrodes being configured to inject a current and to measure electrical signals in response to the injected current; and

a processing unit configured to determine anatomical information about the heart by detecting a boundary of the heart based at least in part on impedance information generated based on the measured signals, wherein;

the anatomical information accounts for a change in conductivity at the cardiac chamber boundary with a first conductivity inside the cardiac chamber boundary and a second conductivity outside the cardiac chamber boundary, the first conductivity being different from the second conductivity; and

the anatomical information comprises a representation of at least a portion of a boundary of the heart.

12. The system of claim 11, wherein the processing unit is configured to determine the anatomical information based at least in part on impedance information generated based on the measured signals at the different catheter positions.

13. The system of claim 12, wherein the impedance information is based on a conductivity contrast between blood and surrounding tissue.

14. The system of claim 11, wherein the processing unit is configured to determine the anatomical information by determining closed and parameterized surfaces based on the measured signals, the surfaces each representing a surface at which the conductivity changes.

15. The system of claim 14, wherein the processing unit is configured to, for each of the determined surfaces, select one or more regions of the surface corresponding to a boundary of a portion of the heart based at least in part on a distance between a portion of the surface and the catheter and join the regions of the determined surfaces corresponding to an expected chamber boundary to generate the anatomical information.

16. The system of claim 15, wherein the processing unit is configured to select the one or more regions based at least in part on a magnitude of a distortion field, the distortion field being based at least in part on a difference between a field calculated based on the measurements and a field in a homogonous medium.

17. The system of claim 16, wherein the processing unit is configured to select the one or more regions based at least in part on an error calculation in an optimization used to generate the surface.

18. The system of claim 11, wherein the electrodes on the catheter are further configured to measure cardiac signals in response to electrical activity in the heart and the processing unit is configured to determine physiological information at multiple locations of the boundary of the heart based on the determined positions of the catheter electrodes and the measured cardiac signals.