Method and apparatus for allowing blood flow through an occluded vessel

• US 9,510,855 B2
• Filed: 06/15/2010
• Issued: 12/06/2016
• Est. Priority Date: 06/15/2009
• Status: Active Grant

• Current Assignee: Perflow Medical Ltd.
• Original Assignee: Perflow Medical Ltd.
• Inventors: Rapaport, Avraham, Cibulski, Gilad
• Primary Examiner(s): Eastwood, David C
• Application Number:
  US13/378,053
• Publication Number:
  US 20120089216A1
• Time in Patent Office: 2,366 Days
• Field of Search: 606/191, 606/194, 606/198, 606/200, 606110-115, 606127-128, 606/159, 623 111- 115, 623/1.17
• US Class Current: 1/1
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/2215 having an open distal end
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61F 2/01 Filters implantable into blood vessels
• CPC Class Codes: A61F 2/844 folded prior to deployment
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/88 the wire-like elements formed as helical or spiral coils forming a net-like or mesh-like structure A61F2/90
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61F 2250/0059 temporary
• CPC Class Codes: A61F 2250/0098 radio-opaque, e.g. radio-opaque markers
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

A device arranged to sustain and/or provide at least partial patency of a small blood vessel exhibiting an occlusion, the device constituted of a tubular body expandable from a first small diameter state for manipulation to, and through, the occlusion of the small blood vessel and a second large diameter state, the inner dimensions of the second large diameter state being no more than 50% of the diameter of the small blood vessel at the occlusion location, the device presenting a conduit for blood flow through the occlusion when in the large diameter state. In one embodiment the small blood vessel is an intracranial blood vessel.

Claims

1. A device positionable within a small intracranial blood vessel exhibiting an occlusion caused by a thrombosis or an embolism, the device comprising

a self expandable tubular body, said tubular body configured to be constrained in a first small diameter state for manipulation to, and through, the occlusion of the small blood vessel, and a second large diameter state for when said tubular body is deployed within the occlusion,

a delivery catheter for delivery of said tubular body;

said device comprising a first member coupled to a proximal end of said tubular body, and a second member coupled to a distal end of said tubular body, said members pullable and pushable relative to each other to change a cross sectional area of said tubular body after self-expansion thereof;

wherein at least a portion of said first member is an integral part of said self expandable tubular body, formed as a local elongated protrusion of said self expandable tubular body;

wherein said first member is extendable through the delivery catheter, running through the catheter and out of a proximal end thereof;

wherein said second member comprises a filament that extends distally beyond said distal end of said tubular body; and

wherein said first and second members are movable with respect to each other to compress said tubular body to increase its diameter or stretch said tubular body to decrease its diameter.

2. The device according to claim 1, wherein the tubular body in said second large diameter state does not urge to expand beyond 50% of the diameter of the small blood vessel.

3. The device according to claim 1, wherein the tubular body in the second large diameter state exhibits a length at least 14 times the inner diameter of the tubular body in the second large diameter state.

4. The device according to claim 1, wherein the tubular body in the second large diameter state exhibits an inner diameter no more than twice the inner diameter of the tubular body in the first small diameter state.

5. The device according to claim 1, further comprising a distal filtering extension coupled to said distal end of said tubular body.

6. The device according to claim 5, wherein the distal filtering extension is arranged to expand to meet the inner wall of the small blood vessel distal of said occlusion.

7. The device according to claim 1, further comprising a proximal securing member coupled to a proximal end of said tubular body, said proximal securing member arranged to expand to meet the inner wall of the small blood vessel.

8. The device according to claim 1, wherein in said collapsed, first diameter state said device is retractable to be withdrawn by pulling on said first member.

9. The device according to claim 1, wherein the device is coated with an elastic non-porous material.

10. The device according to claim 1, wherein the device is constituted of self expanding braided filaments.

11. The device according to claim 1, further comprising a clot retrieval device arranged to retrieve at least a portion of the occlusion, said clot retrieval device in communication with said tubular body and exhibiting a diameter greater than 50% of the diameter of the small blood vessel at the occlusion location.

12. The device according to claim 11, wherein said clot retrieval device comprises a braid external to said tubular body, said braid adapted to trap at least a portion of the occlusion when said tubular body is expanded within said occlusion.

13. The device according to claim 12, wherein said tubular body comprises filaments, and said clot retrieval body comprises 50% or less filaments than said tubular body.

14. The device according to claim 1, wherein the tubular body is coated with an elastic porous material.

15. The device according to claim 1, wherein a medicament is delivered to the occlusion through the device when the device is expanded to the second large diameter state within the occlusion.

16. The device according to claim 1, wherein both of said members extend throughout the delivery catheter and are long enough to be accessible to a user for actuating at least one of said pulling or pushing while said device is inside the body.

17. The device according to claim 1, wherein at least one of said members is configured for delivering medical means to the site of the occlusion.

18. The device according to claim 1, wherein said device is arranged to sustain at least partial patency of a small blood vessel exhibiting an occlusion.

19. The device according to claim 1, wherein in said second large diameter state said device presents a conduit through said tubular body for blood to flow through the occlusion.

20. The device according to claim 1, wherein the inner dimensions of said second large diameter state are no more than 50% of the diameter of the small blood vessel at the occlusion location.

21. The device according to claim 1, wherein said second member comprises a cross sectional area smaller than 0.1 mm^2.

22. The device according to claim 1, wherein said tubular body is configured to be maintained in said second large diameter state using said first and second members, wherein in said second large diameter state said tubular body is expanded only enough to engage said occlusion to withdraw at least a portion of said occlusion between said tubular body and a wall of said small blood vessel.

23. The device according to claim 1, wherein said second member is integrally attached to said distal end of said tubular body.

24. The device according to claim 1, wherein said first and second members are pullable and pushable relative to each other to selectively increase a cross sectional area of said tubular body when said tubular body is in said self-expanded state.

25. The device according to claim 1, wherein said members are pullable and pushable relative to each other to increase and decrease a cross sectional area of said tubular body.

26. The device according to claim 1, wherein said tubular body exhibits an outward radial force sufficient to capture at least a portion of said occlusion between said tubular body and inner walls of a lumen of said blood vessel, said outward radial force small enough so as to not traumatize the walls of said blood vessel.

27. The device according to claim 26, wherein said occlusion decreases a diameter of said inner walls by at least 75%.

28. The device according to claim 1, wherein said first member is interweaved to said proximal end of said self expandable tubular body.

29. The device according to claim 1, wherein said first member is looped into a braided construction of said proximal end of said self expandable tubular body.

30. The device according to claim 1 wherein said tubular body provides enough radial force at diameters up to said second large diameter state so as to prevent movement of said tubular body in said occlusion while being small enough so as not to traumatize the walls of said blood vessel.

31. The device according to claim 1, wherein a distal end of said second member defines a distal-most end of said device.