Composite mesh including a 3D mesh and a non porous film of oxidized cellulose from bacterial cellulose origin

• US 9,510,928 B2
• Filed: 01/15/2015
• Issued: 12/06/2016
• Est. Priority Date: 11/07/2008
• Status: Active Grant

• Current Assignee: Sofradim Production
• Original Assignee: Sofradim Production
• Inventors: Bayon, Yves, Ladet, Sbastien, Lefranc, Olivier, Gravagna, Philippe
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): AL-AWADI, DANAH J
• Application Number:
  US14/597,573
• Publication Number:
  US 20150127028A1
• Time in Patent Office: 691 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2002/0081 directly machined on the prosthetic surface, e.g. holes, grooves A61F2/30771 takes precedence
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue of bone tissue onto implantable joints A61F2002/30932
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 1/02 Cellulose; Modified cellulose
• CPC Class Codes: Y10T 156/10 Methods of surface bonding and/or assembly therefor

Abstract

The present invention relates to a composite implant comprising: a prosthetic fabric having a first side and a second side, a non-porous film of bacterial cellulose secured to the first side of the fabric. The invention further relates to a method of making such an implant.

Claims

1. A composite implant comprising:

a porous prosthetic knit fabric having a first side and a second side, and

a non-porous film of bacterial cellulose secured to the first side of the fabric, wherein the non-porous film of bacterial cellulose prevents the formation of tissue adhesions on the first side of the porous prosthetic knit fabric and the second side of the porous prosthetic knit fabric is porous and open to postsurgical cell colonization.

2. A composite implant as in claim 1 wherein the non-porous film of bacterial cellulose is oxidized.

3. A composite implant as in claim 1, wherein the non-porous film of bacterial cellulose is derived from Acetobacter xylinum.

4. A composite implant as claim 1, wherein the porous prosthetic knit fabric comprises a three-dimensional knit.

5. A composite implant as in claim 1 wherein the porous prosthetic knit fabric has a thickness and the non-porous film of bacterial cellulose penetrates into the porous prosthetic knit fabric to a depth of less than 50% of the thickness of the porous prosthetic knit fabric.

6. A composite implant as in claim 1 wherein the non-porous film is a uniform coating coextensive with and covering the entire first surface of the porous prosthetic knit fabric.

7. A composite implant as in claim 1 wherein the porous prosthetic knit fabric has a thickness of between 1 and 3 mm.

8. A composite implant as in claim 7 wherein the porous prosthetic knit fabric has a weight of less than about 100 g/m².

9. A composite implant as in claim 1 wherein the non-porous film is linked to the porous prosthetic knit fabric by surface penetration, and cannot be delaminated, so as not to constitute a plane of separation.

10. A composite implant as in claim 2 wherein the bacterial cellulose has a degree of oxidation from about 0.1 to about 0.9.

11. A composite implant as in claim 2 wherein the bacterial cellulose has a degree of oxidation from about 0.2 to about 0.65.

12. A composite implant comprising:

a porous prosthetic three-dimensional knit fabric having a first side and a second side, and

a non-porous film of oxidized bacterial cellulose linked to the first side of the porous prosthetic three-dimensional knit fabric so as not to constitute a plane of separation and the non-porous film cannot be delaminated, wherein the non-porous film of bacterial cellulose prevents the formation of tissue adhesions on the first side of the porous prosthetic three-dimensional knit fabric and the second side of the porous prosthetic three-dimensional knit fabric is porous and open to postsurgical cell colonization.

13. A composite implant as in claim 12 wherein the non-porous film is a uniform coating coextensive with and covering the entire first surface of the porous prosthetic three-dimensional knit fabric.

14. A composite implant as in claim 12 wherein the porous prosthetic three-dimensional knit fabric has a thickness of between 1 and 3 mm.

15. A composite implant as in claim 14 wherein the porous prosthetic three-dimensional knit fabric has a weight of less than about 100 g/m².

16. A composite implant as in claim 12 wherein the oxidized bacterial cellulose has a degree of oxidation from about 0.1 to about 0.9.

17. A composite implant as in claim 12 wherein the oxidized bacterial cellulose has a degree of oxidation from about 0.2 to about 0.65.

18. A composite implant as in claim 12, wherein the non-porous film of oxidized bacterial cellulose is derived from Acetobacter xylinum.