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Anti-complement C1s antibodies and methods of inhibiting complement C1s activity

  • US 9,512,233 B2
  • Filed: 05/11/2015
  • Issued: 12/06/2016
  • Est. Priority Date: 10/25/2012
  • Status: Active Grant
First Claim
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1. A method of inhibiting complement C1s activity in an individual, the method comprising administering to the individual an effective amount of an antibody that:

  • i) selectively binds active form of complement component C1s compared to inactive C1s; and

    ii) inhibits complement C1s activity by at least 60% in a protease assay.

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