Anti-complement C1s antibodies and methods of inhibiting complement C1s activity
First Claim
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1. A method of inhibiting complement C1s activity in an individual, the method comprising administering to the individual an effective amount of an antibody that:
- i) selectively binds active form of complement component C1s compared to inactive C1s; and
ii) inhibits complement C1s activity by at least 60% in a protease assay.
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Abstract
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. In some embodiments, such anti-complement C1s antibodies inhibit proteolytic activity of C1s. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
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Citations
41 Claims
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1. A method of inhibiting complement C1s activity in an individual, the method comprising administering to the individual an effective amount of an antibody that:
- i) selectively binds active form of complement component C1s compared to inactive C1s; and
ii) inhibits complement C1s activity by at least 60% in a protease assay. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 26, 27, 28, 29, 30, 31, 32, 33)
- i) selectively binds active form of complement component C1s compared to inactive C1s; and
- 15. A humanized antibody that inhibits complement C1s activity, wherein the humanized antibody selectively binds active form of complement component C1s compared to inactive C1s and wherein the humanized antibody inhibits complement C1s activity by at least 60% in a protease assay.
Specification