Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
First Claim
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1. A method of upregulating a function of and/or the expression of an Antiviral gene polynucleotide in patient cells or tissues in vivo or in vitro comprising:
- contacting said cells or tissues with at least one antisense oligonucleotide of 12 to 30 nucleotides in length that targets and specifically hybridizes to a complementary 12 to 30 nucleotide region of a natural antisense polynucleotide of the Antiviral gene polynucleotide selected from a IF1H1 (MDA5) gene having SEQ ID NO;
2 wherein said natural antisense polynucleotide comprises SEQ ID NOS;
7 or 8;
thereby upregulating a function of and/or the expression of the Antiviral gene polynucleotide in patient cells or tissues in vivo or in vitro.
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Abstract
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Antiviral gene, in particular, by targeting natural antisense polynucleotides of an Antiviral gene. The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Antiviral genes.
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10 Claims
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1. A method of upregulating a function of and/or the expression of an Antiviral gene polynucleotide in patient cells or tissues in vivo or in vitro comprising:
contacting said cells or tissues with at least one antisense oligonucleotide of 12 to 30 nucleotides in length that targets and specifically hybridizes to a complementary 12 to 30 nucleotide region of a natural antisense polynucleotide of the Antiviral gene polynucleotide selected from a IF1H1 (MDA5) gene having SEQ ID NO;
2 wherein said natural antisense polynucleotide comprises SEQ ID NOS;
7 or 8;
thereby upregulating a function of and/or the expression of the Antiviral gene polynucleotide in patient cells or tissues in vivo or in vitro.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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