Method and apparatus for magnetic resonance imaging

• US 9,513,358 B2
• Filed: 03/12/2014
• Issued: 12/06/2016
• Est. Priority Date: 03/12/2013
• Status: Active Grant

• Current Assignee: Vaposun Inc.
• Original Assignee: Vaposun Inc.
• Inventors: Levin, Pavel
• Primary Examiner(s): Hyder, G. M.
• Application Number:
  US14/205,507
• Publication Number:
  US 20140266195A1
• Time in Patent Office: 1,000 Days
• US Class Current: 1/1
• CPC Class Codes: G01N 24/081 Making measurements of geologic samples, e.g. measurements of moisture, pH, porosity, permeability, tortuosity or viscosity
• CPC Class Codes: G01N 24/084 Detection of potentially hazardous samples, e.g. toxic samples, explosives, drugs, firearms, weapons
• CPC Class Codes: G01R 33/5602 by filtering or weighting based on different relaxation times within the sample, e.g. T1 weighting using an inversion pulse
• CPC Class Codes: G01R 33/56341 Diffusion imaging
• CPC Class Codes: G01R 33/56366 Perfusion imaging
• CPC Class Codes: G01R 33/56509 due to motion, displacement or flow, e.g. gradient moment nulling G01R33/567 takes precedence

Abstract

The method and system for correcting motion-induced phase errors in Magnetic Resonance Imaging (MRI) use a phase shift of the non-phase encoded reference echo-signal accumulated during the diffusion-weighting in order to characterize bulk motion and tissue deformation and to compensate their effect for correcting the diffusion/perfusion-weighted image. The sequences unbalanced with respect to the first motion derivative are used for distinguishing the perfusion component. The MRI apparatus provides additional excitation resonance-frequency ranges for forming the reference echo signals.

Claims

1. A method for magnetic resonance imaging, wherein an imaging volume is subjected to at least one sequence of resonance frequency (RF) pulses and gradient magnetic field pulses (gradients), each RF pulse of the at least one sequence is applied in a presence of a gradient, the method comprising, in the at least one sequence:

applying at least one first excitation RF pulse within at least one first excitation resonance-frequency range in order to excite transverse magnetization within at least one first slice location within the imaging volume and in order to form at least one first echo signal from the first slice location;

applying at least one second excitation RF pulse within at least one second excitation resonance-frequency range in order to excite transverse magnetization within at least one second slice location within the imaging volume, the at least one second slice location is distinguished from the at least one first slice location, and in order to form, prior to the at least one first echo signal, at least one second echo signal from the at least one second slice location; and

acquiring the at least one first and the at least one second echo signals in order to form a corrected data set,

wherein, of the at least one first and the at least one second echo signals, at least one echo signal is formed with phase encoding, at least another echo signal is at least one reference echo signal;

at least one phase shift of the at least one reference echo signal is at least one reference phase shift, a motion-related phase shift of the at least one echo signal is compensated based on the at least one reference phase shift.

2. The method of claim 1, wherein, the at least one first excitation RF pulse is applied in a presence of at least one first gradient;

the at least one second excitation RF pulse is applied, after the at least one first excitation RF pulse, in a presence of at least one second gradient;

the at least one reference echo signal is formed without phase encoding.

3. The method of claim 2, wherein the at least one second gradient is at least one diffusion-weighting gradient applied along at least one diffusion-weighting direction;

the at least one second excitation RF pulse is at least one reference excitation RF pulse, which is applied within at least one reference excitation resonance-frequency range in a presence of the at least one diffusion-weighting gradient;

the acquiring of the at least one second echo signal is performed in a presence of the at least one diffusion-weighting gradient in order to determine the reference phase shift;

the acquiring of the at least one first echo signal is performed in a presence of at least one readout gradient in order to phase encode a location within the first slice location.

4. The method of claim 3, wherein at least one balancing RF pulse is additionally applied in a presence of the at least one diffusion-weighting gradient in order to balance transverse magnetization within the at least one second slice location after the acquiring of the at least one reference echo signal and prior to the acquiring of the at least one first echo signal.

5. The method of claim 3, wherein the at least one reference excitation RF pulse is applied within at least two reference excitation resonance-frequency ranges;

the at least one reference echo signal from the at least one second slice location is at least two reference echo signals from at least two second slice locations;

the at least one reference phase shift is at least two reference phase shifts;

a gradient of the at least two reference phase shifts with respect to the at least one diffusion-weighting direction is determined in order to characterize deformation along the at least one diffusion-weighting direction.

6. The method of claim 5, wherein at least one compensation sufficiently uniform magnetic field pulse dimensioned to compensate the at least one motion-related phase shift and/or at least one compensation gradient magnetic field pulse dimensioned to compensate the gradient of the at least two phase shifts with respect to the at least one diffusion-weighting gradient direction are applied prior to the acquiring of the at least one first echo signal.

7. The method of claim 3, wherein the at least one diffusion-weighting gradient comprises at least one pair of diffusion-weighting gradients having same polarity;

a refocusing RF pulse is applied about symmetrically between diffusion-weighting gradients of the at least one pair in order to form a symmetrical diffusion-weighted sequence, which is characterized by a first derivative of the at least one reference phase shift being about compensated, in order to characterize transverse magnetization diffusion in the at least one first slice location.

8. The method of claim 3, wherein the at least one diffusion-weighting gradient comprises at least one pair of diffusion-weighting gradients having same polarity;

a refocusing RF pulse is applied with asymmetrical shift between diffusion-weighting gradients of the at least one pair in order to form an asymmetrical diffusion-weighted sequence, which is characterized by a first derivative of the at least one reference phase shift being uncompensated, in order to characterize flow and/or perfusion in the at least one first slice location.

9. The method of claim 3, wherein the at least one diffusion-weighting gradient comprises at least one pair of diffusion-weighting gradients having opposite polarities in order to form an asymmetrical diffusion-weighted sequence, which is characterized by a first derivative of the at least one reference phase shift being uncompensated, in order to characterize flow and/or perfusion in the at least one first slice location.

10. The method of claim 3, wherein the at least one first excitation RF pulse and the at least one reference excitation RF pulse are applied with a partial flipping angle 15-60°

, preferably 20-30°

;

the at least one reference excitation RF pulse is applied with a flipping angle at most equal to the flipping angle of the at least one first excitation RF pulse;

the at least one diffusion-weighting gradient is a unipolar diffusion-weighting gradient;

the at least one diffusion-weighting direction is about the magnetic field direction in order to form an asymmetrical diffusion-weighted sequence, which is characterized by a first derivative of the at least one reference phase shift being uncompensated, in order to characterize a transverse magnetization drift along the magnetic field direction in the at least one first slice location.

11. A method for magnetic resonance imaging, wherein an imaging volume is subjected to at least one first and at least one second diffusion-weighted sequences of resonance frequency (RF) pulses and gradient magnetic field pulses (gradients), in order to form, correspondingly, a first and a second corrected data sets, the method comprising, in each of the at least one first and the at least one second diffusion-weighted sequences,

applying at least one first excitation RF pulse within at least one first excitation resonance-frequency range in a presence of a slice-selection gradient in order to excite transverse magnetization within the at least one first slice location within the imaging volume and to in order form at least one first echo signal from the at least one first slice location;

applying, after the at least one first excitation RF pulse, at least one reference excitation RF pulse within at least one second excitation resonance-frequency range in a presence of at least one diffusion-weighted gradient in order to excite transverse magnetization within at least one second slice location within the imaging volume, the at least one second slice location is distinguished from the at least one first slice location, and in order to form, prior to the at least one first echo signal, at least one reference echo signal from the at least one second slice location; and

acquiring the at least one first echo signal with phase encoding and the at least one second echo signal without phase encoding, at least one phase shift of the at least one reference echo signal, which is the at least one second echo signal, is at least one reference phase shift, the at least one reference phase shift is determined in order to compensate a motion-related phase shift of the at least one first echo signal,

wherein, the second diffusion-weighted sequence is asymmetrical, which is characterized by a first derivative of the at least one reference phase shift being uncompensated, the at least one reference phase shift of the at least one first diffusion-weighted sequence is being sufficiently distinguished from the at least one reference phase shift of the at least one second diffusion-weighted sequence in order to distinguish a flow and/or perfusion component from a diffusion component of transverse magnetization decay in the first slice location based on a comparison of the first and the second corrected data sets.

12. The method of claim 11, wherein the first diffusion-weighted sequence and the second diffusion-weighted sequence are both asymmetrical and characterized by the reference phase shifts of said first and second sequences being mutually opposite.

13. The method of claim 11, wherein the first diffusion-weighted sequence is about symmetrical, which is characterized by a first derivative of the at least one reference phase shift being about compensated, in order to characterize the diffusion component of the transverse magnetization decay in the first slice location;

the second diffusion-weighted sequence comprises at least six asymmetrical sequences having different diffusion-weighting directions in order to characterize a perfusion tensor in the first slice location after eliminating the diffusion component.

14. The method of claim 11, wherein, in each of the first and the second diffusion-weighted sequences, the at least one first excitation RF pulse is applied with a partial flipping angle being at most 60°

, the diffusion-weighting gradient is unipolar, wherein, the unipolar diffusion-weighting gradient of the first diffusion-weighted sequence is applied about along the direction transversal to the magnetic field;

the unipolar diffusion-weighting gradient of the second diffusion-weighted sequence is applied about along the magnetic field direction to distinguish drift component of transverse magnetization decay in the first slice location, in order to characterize a transverse magnetization drift and/or a fraction of fluid.

15. An apparatus for magnetic resonance imaging comprising:

a resonance frequency (RF) coil means and a gradient magnetic coil means in order to subject an imaging volume to a sequence of RF pulses and gradient magnetic field pulses (gradients), each RF pulse of the sequence is applied in a presence of a gradient;

a RF coil control means and a magnetic coil control means in order to apply at least one first excitation RF pulse within at least one first excitation resonance-frequency range, for exciting transverse magnetization within the at least one first slice location within the imaging volume and for forming at least one first echo signal from the at least one first slice location, and in order to apply at least one second excitation RF pulse within at least one second excitation resonance-frequency range, for exciting transverse magnetization within at least one second slice location within the imaging volume, the at least one second slice location is distinguished from the at least one first slice location, and for forming, prior to the at least one first echo signal, at least one second echo signal from the at least one second slice location;

a receiver means in order to acquire the at least one first and the at least one second echo signals in order to form a corrected data set, the receiver means is adjusted to acquire, of the at least one first and the at least one second echo signals, at least one echo signal with phase encoding, wherein, at least another echo signal is at least one reference echo signal, at least one phase shift of the at least one reference echo signal is at least one reference phase shift; and

a processor means in order to compensate a motion-related phase shift of the at least one echo signal based on the at least one reference phase shift.

16. The apparatus of claim 15, wherein the RF coil control means is additionally adjusted to apply the at least one first excitation RF pulse in a presence of at least one first gradient and to apply, after the at least one first excitation RF pulse, the at least one second excitation RF pulse in a presence of at least one second gradient;

the receiver means is additionally adjusted to acquire the at least one reference echo signal without phase encoding.

17. The apparatus of claim 16, wherein the magnetic coil control means is additionally adjusted to apply at least one second gradient, which is at least one diffusion-weighting gradient applied along at least one diffusion-weighting direction;

the RF coil control means is additionally adjusted to apply the at least one second excitation RF pulse, which is the at least one reference excitation RF pulse applied within at least one reference excitation resonance-frequency range, in a presence of the at least one diffusion-weighting gradient;

the receiver means is additionally adjusted to acquire the at least one second echo signal in a presence of the at least one diffusion-weighting gradient in order to determine the reference phase shift and to acquire the at least one first echo signal in a presence of at least one readout gradient in order to phase encode a location within the first slice location.

18. The apparatus of claim 17, wherein, the RF coil control means is additionally adjusted to apply at least one balancing RF pulse in a presence of the at least one diffusion-weighting gradient in order to balance transverse magnetization within the at least one second slice location after the acquiring of the at least one reference echo signal and prior to the acquiring of the at least one first echo signal.

19. The apparatus of claim 17, wherein the RF coil control means is additionally adjusted to apply the at least one reference excitation RF pulse within at least two reference excitation resonance-frequency ranges, the at least one reference echo signal from at least one second slice location is at least two reference echo signals from at least two second slice locations, the at least one reference phase shift is at least two reference phase shifts;

and the processor means is additionally programmed to determine a gradient of the at least two reference phase shifts with respect to the at least one diffusion-weighting direction in order to characterize deformation along the at least one diffusion-weighting direction.

20. The apparatus of claim 19, additionally comprising the uniform magnetic coil means in order to apply, prior to the acquiring of the at least one first echo signal, at least one compensation sufficiently uniform magnetic field pulse dimensioned to compensate the at least one reference phase shift;

and/or the magnetic coil control means is additionally adjusted in order to apply, prior to the acquiring of the at least one first echo signal, at least one compensation gradient magnetic field pulse dimensioned to compensate the gradient of the at least two phase shifts with respect to the at least one diffusion-weighting gradient direction.