Method and system for directing a localized biological response to an implant
First Claim
1. A system comprising:
- an implant configured to be placed within a mammalian body, the implant configured to sense an analyte within the mammalian body, the implant having a first sensitivity to the analyte before a foreign body response of the mammalian body and a second sensitivity less than the first sensitivity after the foreign body response of the mammalian body;
a first patch configured to be placed on a surface of the mammalian body and to deliver a first tissue response modifier such that the first tissue response modifier does not reach systemic levels in the mammalian body, the first tissue response modifier configured to, at least one of, (1) minimize a first response of the mammalian body to the implantation of the implant or (2) enhance a second response of the mammalian body to the implantation of the implant; and
a second patch configured to be placed on the surface of the mammalian body over the implant after the first patch is placed on the surface of the surface of the mammalian body, the second patch configured to (1) receive a signal from the implant associated with the analyte, and (2) deliver a second tissue response modifier through an epidermis of the mammalian body to reduce or eliminate the foreign body response of the mammalian body, the second patch configured to deliver the tissue response modifier such that the tissue response modifier does not reach systemic levels in the mammalian body.
2 Assignments
0 Petitions
Accused Products
Abstract
The invention provides methods for directing a localized biological response of a mammalian body to an implant disposed within the body. In one embodiment, a delivery system is positioned outside the body and adjacent to the implant within the body. The delivery system comprises a first tissue response modifier effective for directing a localized biological response of the body to the implant. The tissue response modifier is nonsurgically delivered from the delivery system into the body in a quantity effective to direct the localized biological response of the body to the implant. The invention also provides an implant system for long-term use comprising an implant and nonsurgical means for delivering a tissue response modifier through the epidermis of the body, the tissue response modifier effective for directing a localized biological response of the body to the implant.
88 Citations
22 Claims
-
1. A system comprising:
-
an implant configured to be placed within a mammalian body, the implant configured to sense an analyte within the mammalian body, the implant having a first sensitivity to the analyte before a foreign body response of the mammalian body and a second sensitivity less than the first sensitivity after the foreign body response of the mammalian body; a first patch configured to be placed on a surface of the mammalian body and to deliver a first tissue response modifier such that the first tissue response modifier does not reach systemic levels in the mammalian body, the first tissue response modifier configured to, at least one of, (1) minimize a first response of the mammalian body to the implantation of the implant or (2) enhance a second response of the mammalian body to the implantation of the implant; and a second patch configured to be placed on the surface of the mammalian body over the implant after the first patch is placed on the surface of the surface of the mammalian body, the second patch configured to (1) receive a signal from the implant associated with the analyte, and (2) deliver a second tissue response modifier through an epidermis of the mammalian body to reduce or eliminate the foreign body response of the mammalian body, the second patch configured to deliver the tissue response modifier such that the tissue response modifier does not reach systemic levels in the mammalian body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. A system, comprising:
-
an implant configured to be placed within a mammalian body, the implant configured to measure an analyte of the mammalian body, the implant having a first sensitivity to the analyte before a foreign body response of the mammalian body and a second sensitivity less than the first sensitivity after the foreign body response of the mammalian body; a first patch configured to be placed on a surface of the mammalian body over the implant, the first patch configured to (1) receive a signal from the implant associated with the analyte, and (2) deliver a first tissue response modifier through an epidermis of the mammalian body to reduce or eliminate the foreign body response of the mammalian body, the first patch configured to deliver the tissue response modifier such that the tissue response modifier does not reach systemic levels in the mammalian body; and a second patch configured to be placed on the mammalian body after the first patch, the second patch configured to (1) receive the signal from the implant and (2) deliver a second tissue response modifier through an epidermis of the mammalian body such that the second tissue response modifier does not reach systemic levels in the mammalian body. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
Specification