Method and system for providing information from a patient-specific model of blood flow

• US 9,517,040 B2
• Filed: 02/11/2014
• Issued: 12/13/2016
• Est. Priority Date: 05/14/2012
• Status: Active Grant

• Current Assignee: Heartflow Inc.
• Original Assignee: Heartflow Inc.
• Inventors: Hart, Gregory R., Stevens, John H.
• Primary Examiner(s): Thangavelu, Kandasamy
• Application Number:
  US14/177,630
• Publication Number:
  US 20140292752A1
• Time in Patent Office: 1,036 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2034/104 Modelling the effect of the tool, e.g. the effect of an implanted prosthesis or for predicting the effect of ablation or burring
• CPC Class Codes: A61B 2576/023 for the heart
• CPC Class Codes: A61B 34/10 Computer-aided planning, simulation or modelling of surgical operations
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/7425 Displaying combinations of multiple images regardless of image source, e.g. displaying a reference anatomical image with a live image geometric transforms for image registration G06T3/14; enhancement using image fusion G06T5/50; algorithms for registration of images G06T7/30
• CPC Class Codes: A61B 5/7445 Display arrangements, e.g. multiple display units
• CPC Class Codes: A61B 5/748 Selection of a region of interest, e.g. using a graphics tablet
• CPC Class Codes: A61B 6/03 Computed tomography [CT] echo-tomography A61B8/14
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/466 adapted to display 3D data
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 6/5217 extracting a diagnostic or physiological parameter from medical diagnostic data
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: G06F 3/017 : Gesture based interaction, e.g. based on a set of recognized hand gestures interaction based on gestures traced on a digitiser G06F3/04883
• CPC Class Codes: G06F 3/04815 : Interaction with a metaphor-based environment or interaction object displayed as three-dimensional, e.g. changing the user viewpoint with respect to the environment or object
• CPC Class Codes: G06F 3/0486 : Drag-and-drop
• CPC Class Codes: G06F 3/0488 : using a touch-screen or digitiser, e.g. input of commands through traced gestures
• CPC Class Codes: G06F 30/20 : Design optimisation, verification or simulation optimisation, verification or simulation of circuit designs G06F30/30
• CPC Class Codes: G06T 15/00 : 3D [Three Dimensional] image rendering
• CPC Class Codes: G06T 17/00 : Three dimensional [3D] modelling, e.g. data description of 3D objects
• CPC Class Codes: G06T 19/20 : Editing of 3D images, e.g. changing shapes or colours, aligning objects or positioning parts
• CPC Class Codes: G06T 2200/04 : involving 3D image data
• CPC Class Codes: G06T 2200/24 : involving graphical user interfaces [GUIs]
• CPC Class Codes: G06T 2210/41 : Medical
• CPC Class Codes: G06T 2219/2016 : Rotation, translation, scaling
• CPC Class Codes: G16B 5/00 : ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
• CPC Class Codes: G16H 30/20 : for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 50/50 : for simulation or modelling of medical disorders
• CPC Class Codes: Y02A 90/10 : Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.

Claims

1. A method for providing patient-specific blood flow information using at least a computer system, the method comprising:

receiving over an electronic network, at the computer system, patient-specific anatomical data;

generating, based on the received patient-specific anatomical data, a geometric model representing at least a portion of an anatomical structure of a patient, and a reduced-order model of the portion of the anatomical structure;

transmitting over the electronic network one or both of the geometric model and the reduced-order model to a portable computer including a touchscreen;

receiving over the electronic network, at the computer system, a user intervention input entered by a user on the touchscreen indicating a potential treatment of the anatomical structure that initiates a modification of the reduced-order model;

calculating, at the computer system, at least one blood flow characteristic based on the received user intervention input and the modification of the reduced-order model; and

transmitting over the electronic network the calculated at least one blood flow characteristic to the portable computer.

2. The method of claim 1, wherein the geometric model is a three-dimensional model.

3. The method of claim 1, wherein the patient-specific anatomical data includes imaging data of at least a portion of an anatomical structure of a patient.

4. The method of claim 3, wherein the anatomical structure includes at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta.

5. The method of claim 3, wherein the anatomical structure includes at least one of a portion of a plurality of arteries in the patient'"'"'s heart, neck, head, thorax, abdomen, arms, or legs.

6. The method of claim 1, wherein the modification of the reduced-order model is initiated on the portable computer.

7. The method of claim 1, wherein the modification of the reduced-order model is initiated on the computer system.

8. The method of claim 1, wherein the modification corresponds to placement of a stent.

9. The method of claim 1, wherein the modification corresponds to a formation of a bypass.

10. The method of claim 1, wherein the electronic network is chosen from a wired and a wireless network.

11. A system for providing patient-specific blood flow information for a patient, the system comprising at least:

a computer system including a processor configured to;

receive over an electronic network patient-specific data anatomical data;

generate, based on the received patient-specific anatomical data, a geometric model representing at least a portion of an anatomical structure of a patient, and a reduced-order model of the portion of the anatomical structure;

transmit over the electronic network one or both of the geometric model and the reduced-order model to a portable computer including a touchscreen;

receive over the electronic network a user intervention input entered by a user on the touchscreen indicating a potential treatment of the anatomical structure that initiates a modification of the reduced-order model;

calculate at least one blood flow characteristic based on the received user intervention input and the modification of the reduced-order model; and

transmit over the electronic network the calculated at least one blood flow characteristic to the portable computer.

12. The system of claim 11, wherein the geometric model is a three-dimensional model.

13. The system of claim 11, wherein the patient-specific anatomical data includes imaging data of at least a portion of an anatomical structure of a patient.

14. The system of claim 13, wherein the anatomical structure includes at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta.

15. The system of claim 13, wherein the anatomical structure includes at least one of a portion of a plurality of arteries in the patient'"'"'s heart, neck, head, thorax, abdomen, arms, or legs.

16. The system of claim 11, wherein the modification of the reduced-order model is initiated on the portable computer.

17. The system of claim 11, wherein the modification of the reduced-order model is initiated on the computer system.

18. The system of claim 11, wherein the modification corresponds to placement of a stent.

19. The system of claim 11, wherein the modification corresponds to a formation of a bypass.

20. The system of claim 11, wherein the electronic network is chosen from a wired and a wireless network.

21. A non-transitory computer readable medium for use on at least a computer system containing computer-executable programming instructions for providing patient-specific blood flow information, the instructions being executable by the computer system for:

receiving over an electronic network, at the computer system, patient-specific anatomical data;

generating, based on the received patient-specific anatomical data, a geometric model representing at least a portion of an anatomical structure of a patient, and a reduced-order model of the portion of the anatomical structure;

transmitting over the electronic network one or both of the geometric model and the reduced-order model to a portable computer including a touchscreen;

receiving over the electronic network, at the computer system, a user intervention input entered by a user on the touchscreen indicating a potential treatment of the anatomical structure that initiates a modification of the reduced-order model;

calculating at least one blood flow characteristic based on the received user intervention input and the modification of the reduced-order model; and

transmitting the calculated at least one blood flow characteristic to the portable computer.

22. The non-transitory computer readable medium of claim 21, wherein the geometric model is a three-dimensional model.

23. The non-transitory computer readable medium of claim 21, wherein the patient-specific anatomical data includes imaging data of at least a portion of an anatomical structure of a patient.

24. The non-transitory computer readable medium of claim 23, wherein the anatomical structure includes at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta.

25. The non-transitory computer readable medium of claim 23, wherein the anatomical structure includes at least one of a portion of a plurality of arteries in the patient'"'"'s heart, neck, head, thorax, abdomen, arms, or legs.

26. The non-transitory computer readable medium of claim 21, wherein the modification of the reduced-order model is initiated on the portable computer.

27. The non-transitory computer readable medium of claim 21, wherein the modification of the reduced-order model is initiated on the computer system.

28. The non-transitory computer readable medium of claim 21, wherein the modification corresponds to placement of a stent.

29. The non-transitory computer readable medium of claim 21, wherein the modification corresponds to a formation of a bypass.

30. The non-transitory computer readable medium of claim 21, wherein the electronic network is chosen from a wired and a wireless network.