Medical devices having activated surfaces

• US 9,517,291 B2
• Filed: 02/13/2015
• Issued: 12/13/2016
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Belcheva, Nadya, Abuzaina, Ferass, Elachchabi, Amin, Kapiamba, Mbiya, Hadba, Ahmad Robert
• Primary Examiner(s): Yoon, Tae H
• Application Number:
  US14/621,493
• Publication Number:
  US 20150157769A1
• Time in Patent Office: 669 Days
• Field of Search: 523/205, 427/2.24, 427/2.31
• US Class Current: 1/1
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/043 Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/048 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61L 33/06 Use of macromolecular materials grafting of a monomer onto the substrate A61L33/0088
• CPC Class Codes: C08J 2300/16 Biodegradable polymers
• CPC Class Codes: C08J 7/12 Chemical modification
• CPC Class Codes: C08J 7/14 with acids, their salts or anhydrides
• CPC Class Codes: Y10T 442/20 Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer

Abstract

Implantable biocompatible polymeric medical devices include a substrate with an acid or base-modified surface which is subsequently modified to include click reactive members.

Claims

1. A method of preparing a medical device having an activated surface, the method comprising:

acid-treating at least a portion of a surface of a polymeric medical device to obtain hydrolysis; and

attaching one or more click reactive members to the acid-treated surface of the medical device, wherein the click reactive members are selected from the group consisting of thiols, azides, alkynes, and alkenes.

2. The method according to claim 1, wherein the acid is selected from the group consisting of HCl, HCl₃, HCl₄, H₂SO₃, H₂SO₄, H₃PO₄, HI, HIO₃, HBr, lactic acid and glycolic acid.

3. The method according to claim 1, wherein the click reactive member is selected from the group consisting of thiols and alkenes.

4. The method according to claim 1, wherein the click reactive members are selected from the group consisting of azides and alkynes.

5. The method according to claim 1, wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons.

6. The method according to claim 1, wherein the medical device is a surgical mesh.

7. The method according to claim 1, wherein the medical device comprises a biodegradable polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, copolymers and combinations thereof.

8. The method according to claim 1, wherein the medical device comprises a non-degradable polymer selected from fluorinated polymers, polyolefins, polyamides, polyurethanes, silicones, polyaryletherketone, copolymers and combinations thereof.

9. The method according to claim 1, wherein acid-treating at least a portion of a surface of a medical device is conducted at a temperature between 0°

C. and a glass transition temperature of a material of the medical device.

10. The method according to claim 1, wherein the medical device comprises polybutester.

11. The method according to claim 1, wherein the medical device comprises nylon.

12. The method according to claim 1, wherein the medical device comprises ultra high molecular weight polyethylene.