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System and method for rapid analysis of polycyclic aromatic hydrocarbons

  • US 9,518,960 B2
  • Filed: 10/01/2014
  • Issued: 12/13/2016
  • Est. Priority Date: 10/02/2013
  • Status: Active Grant
First Claim
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1. A method for detecting one or more polycyclic aromatic hydrocarbons (PAHs) in a sample by means of a CO2-based chromatography analysis comprising:

  • providing a sample comprising one or more PAHs for analysis;

    wherein the sample is prepared with, extracted or dissolved in a diluent comprising at least 60% organic solvent, with the proviso that the sample is analyzed without a solvent exchange step;

    applying the sample to a chromatography column with a solid stationary phase comprising inorganic or hybrid particles having a mean particle size of about 0.5 to about 3.5 microns, wherein said particles have a non-polar or polar/non-polar surface functionality, and wherein the particles retain said one or more PAHs;

    eluting the one or more PAHs from the chromatography column by a mobile phase comprising a mixture of liquid CO2 and a modifier to form one or more eluted PAHs;

    wherein the mobile phase has a pre-column dwell volume of about 75 μ

    L to about 500 μ

    L; and

    detecting said one or more eluted PAHs.

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