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Compositions and methods for inducing immune tolerance

  • US 9,522,183 B2
  • Filed: 07/29/2011
  • Issued: 12/20/2016
  • Est. Priority Date: 07/31/2010
  • Status: Active Grant
First Claim
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1. A method for reducing antigen-specific antibodies to a polypeptide antigen in a subject, comprising administering to the subject a pharmaceutical composition comprising a liposome;

  • a CD22, Siglec G, or Siglec-10 glycan ligand; and

    an effective amount of a T cell-dependent MHC class II, B cell-specific polypeptide antigen that is linked to a lipid and co-displayed on the liposome with the CD22, Siglec G, or Siglec-10 glycan ligand;

    to thereby reduce production of antibodies to the antigen by B cells in the subject.

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  • 4 Assignments
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