Compositions and methods for transport across the blood brain barrier
First Claim
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1. A composition comprising:
- a heterologous transporter peptide consisting of SEQ ID NO;
13, wherein amino acid Xaa at position 4 of SEQ ID NO;
13 is tyrosine (Y), glycine (G), or isoleucine (I), Xaa at position 7 is proline (P), and Xaa at position 10 is glycine (G).
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Abstract
Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.
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Citations
16 Claims
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1. A composition comprising:
a heterologous transporter peptide consisting of SEQ ID NO;
13, wherein amino acid Xaa at position 4 of SEQ ID NO;
13 is tyrosine (Y), glycine (G), or isoleucine (I), Xaa at position 7 is proline (P), and Xaa at position 10 is glycine (G).- View Dependent Claims (2, 3, 5)
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4. A composition comprising, a transporter peptide conjugate consisting of:
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a heterologous effector agent; and a heterologous transporter peptide consisting of SEQ ID NO;
13,the heterologous effector agent being conjugated to the heterologous transporter peptide. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification