Intra-abdominal pressure to promote hemostasis and survival

• US 9,522,215 B2
• Filed: 08/08/2014
• Issued: 12/20/2016
• Est. Priority Date: 08/12/2011
• Status: Active Grant

• Current Assignee: Arsenal Medical, Inc
• Original Assignee: Arsenal Medical, Inc
• Inventors: Rago, Adam, Marini, John, Zugates, Gregory T., Helmick, Marc, Sharma, Upma
• Primary Examiner(s): Nguyen, Victor
• Application Number:
  US14/455,117
• Publication Number:
  US 20150012031A1
• Time in Patent Office: 865 Days
• US Class Current: 1/1
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 2400/04 Materials for stopping bleeding
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.

Claims

1. A method of treating a hemorrhage within a cavity, comprising the steps of:

applying a pressure to an interior boundary of the cavity, wherein the pressure is applied by a foam formed inside of the cavity by applying a formulation comprising at least one liquid phase into the cavity, and wherein the pressure is characterized by a transient peak value and at least one steady state value.

2. The method of claim 1, wherein the transient peak value is less than about 84 mmHg.

3. The method of claim 1, wherein the transient peak value is at least about 51 mmHg.

4. The method of claim 1, wherein the transient peak value is at least about 20 mmHg.

5. The method of claim 1, wherein the steady state value is at least about 28 mmHg.

6. The method of claim 1, wherein the steady state value is at least about 14 mmHg.

7. The method of claim 1, wherein the transient peak value occurs within the first three minutes and is followed by the steady state value.

8. The method of claim 7, wherein the steady state value is at least 30% of the transient peak value.

9. The method of claim 7, wherein the steady state value is at least 50% of the transient peak value.

10. The method of claim 7, wherein the steady state value is at least 90% of the transient peak value.

11. The method of claim 1, wherein the cavity is an abdominal cavity, a junctional hemorrhage, a cavity associated with a pelvic hemorrhage, or a pseudocavity.