Movement disorder therapy system and methods of tuning remotely, intelligently and/or automatically
First Claim
1. A method of tuning a movement disorder therapy system comprising steps of:
- instructing a subject having a deep brain stimulation (DBS) device with a first level of DBS parameters to perform a first movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy;
having a physician, clinician, technician or device with sensors determine a score to quantify a first motor symptom(s) of the subject from the first movement disorder test;
operating the subject'"'"'s DBS device under a second level of DBS parameters;
instructing the subject to perform at least one more movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy under the second level of DBS parameters;
having a physician, clinician, technician or device with sensors determine a score to quantify a second motor symptom(s) of the subject during the at least one more movement disorder test;
combining, with a processor, data corresponding to the subject'"'"'s first motor symptom score, data corresponding to the test parameter(s) from the first movement disorder test and/or the first level of DBS parameter(s), data corresponding to the subject'"'"'s second motor symptom score and data corresponding to the test parameter(s) from the another movement disorder test and/or the second level of DBS parameter(s) to generate a tuning map for viewing by a clinician, technician or physician comprising a two-dimensional representation of a three-dimensional graph that illustrates a correlation between the test parameter(s) and/or DBS parameter(s), and the data corresponding to the subject'"'"'s quantified motor symptom(s) scores;
a clinician, technician or physician determining, based at least in part on the tuning map, a new level of DBS parameters;
entering the new level of DBS parameters into the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the new level of DBS parameters; and
the DBS device supplies a stimulation current to the subject'"'"'s brain under the new level of DBS parameters to provide improved DBS therapy.
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Accused Products
Abstract
The present invention relates to methods for remotely and intelligently tuning movement disorder of therapy systems. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson'"'"'s disease and Parkinsonism, Dystonia, Chorea, and Huntington'"'"'s disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely and intelligently or automatically tuning a therapy device using objective quantified movement disorder symptom data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning intelligently, automatically and remotely, allowing for home monitoring of subjects.
78 Citations
20 Claims
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1. A method of tuning a movement disorder therapy system comprising steps of:
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instructing a subject having a deep brain stimulation (DBS) device with a first level of DBS parameters to perform a first movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy; having a physician, clinician, technician or device with sensors determine a score to quantify a first motor symptom(s) of the subject from the first movement disorder test; operating the subject'"'"'s DBS device under a second level of DBS parameters; instructing the subject to perform at least one more movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy under the second level of DBS parameters; having a physician, clinician, technician or device with sensors determine a score to quantify a second motor symptom(s) of the subject during the at least one more movement disorder test; combining, with a processor, data corresponding to the subject'"'"'s first motor symptom score, data corresponding to the test parameter(s) from the first movement disorder test and/or the first level of DBS parameter(s), data corresponding to the subject'"'"'s second motor symptom score and data corresponding to the test parameter(s) from the another movement disorder test and/or the second level of DBS parameter(s) to generate a tuning map for viewing by a clinician, technician or physician comprising a two-dimensional representation of a three-dimensional graph that illustrates a correlation between the test parameter(s) and/or DBS parameter(s), and the data corresponding to the subject'"'"'s quantified motor symptom(s) scores; a clinician, technician or physician determining, based at least in part on the tuning map, a new level of DBS parameters; entering the new level of DBS parameters into the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the new level of DBS parameters; and the DBS device supplies a stimulation current to the subject'"'"'s brain under the new level of DBS parameters to provide improved DBS therapy. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of tuning a movement disorder therapy system comprising steps of:
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instructing a subject having a deep brain stimulation (DBS) device with a first level of DBS parameters to perform a first movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy; having a physician, clinician, technician or device with sensors determine a score to quantify a first motor symptom(s) of the subject from the first movement disorder test; operating the subject'"'"'s DBS device under a second level of DBS parameters; instructing the subject to perform at least one more movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy under the second level of DBS parameters; having a physician, clinician, technician or device with sensors determine a score to quantify a second motor symptom(s) of the subject during the at least one more movement disorder test; combining, with a processor, data corresponding to the subject'"'"'s first quantified motor symptom(s) score, data corresponding to the test parameter(s) from the first movement disorder test and/or the first level of DBS parameter(s), data corresponding to the subject'"'"'s second quantified motor symptom(s) score and data corresponding to the test parameter(s) from the another movement disorder test and/or the second level of DBS parameter(s) to generate a tuning map for viewing by a clinician, technician or physician comprising a two-dimensional representation of a three-dimensional graph wherein the tuning map graphically depicts coded indicators each relating to a quantified motor symptom scores, where the indicators are coded by one or more of color, pattern, or number representing each quantified score; a clinician, technician or physician determining, based at least in part on the tuning map, a new level of DBS parameters; entering the new level of DBS parameters into the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the new level of DBS parameters; and the DBS device supplies a stimulation current to the subject'"'"'s brain under the new level of DBS parameters to provide improved DBS therapy. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method of tuning a movement disorder therapy system comprising steps of:
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instructing a subject having a deep brain stimulation (DBS) device with a first level of DBS parameters to perform a first movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy; having a physician, clinician, technician or device with sensors determine a score to quantify a first motor symptom(s) of the subject from the first movement disorder test; operating the subject'"'"'s DBS device under a second level of DBS parameters; instructing the subject to perform at least one more movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy under the second level of DBS parameters; having a physician, clinician, technician or device with sensors determine a score to quantify a second motor symptom(s) of the subject during the at least one more movement disorder test; combining, with a processor, data corresponding to the subject'"'"'s first quantified motor symptom(s) score, data corresponding to the test parameter(s) from the first movement disorder test and/or the first level of DBS parameter(s), data corresponding to the subject'"'"'s second quantified motor symptom(s) score and data corresponding to the test parameter(s) from the another movement disorder test and/or the second level of DBS parameter(s) to generate a tuning map for viewing by a clinician, technician or physician comprising a two-dimensional representation of a three-dimensional graph, the tuning map further graphically depicting one or more of sensor recordings, subject responses, subject perceptions, clinician observations, clinician scores or device scores; a clinician, technician or physician determining, based at least in part on the tuning map, a new level of DBS parameters; entering the new level of DBS parameters into the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the new level of DBS parameters; and the DBS device supplies a stimulation current to the subject'"'"'s brain under the new level of DBS parameters to provide improved DBS therapy. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification