Systems and methods for detection and quantification of analytes
First Claim
1. A cartridge comprising:
- an input tunnel configured to permit full or partial insertion of a sample collection device adapted to be exposed to a sample;
a sample reservoir configured to hold a fluid and configured to receive the sample from the sample collection device such that the sample and reagents mix in the fluid;
a chemical substrate reservoir configured to hold a substrate solution comprising a chemical substrate, the chemical substrate reservoir fluidicly isolated from the sample reservoir;
an analysis channel configured to receive, from the sample reservoir, the fluid comprising the sample and the reagents mixed therein, the analysis channel further configured to receive, from the chemical substrate reservoir, the substrate solution comprising the chemical substrate; and
a sensor at least partially disposed within the analysis channel, the sensor configured to be exposed to the fluid comprising the sample and the reagents mixed therein from the sample reservoir in the analysis channel such that the reagents indicative of at least one of a presence, absence, or quantity of one or more analytes within the sample localize over the sensor, the sensor further configured to be exposed to the substrate solution comprising the chemical substrate from the chemical substrate reservoir such that the sensor generates an electrical signal indicative of at least one of the presence, absence, or quantity of the one or more analytes within the sample based on reactions between the chemical substrate and the reagents localized at the sensor within the analysis channel.
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Accused Products
Abstract
Devices, systems, and methods for detecting molecules of interest within a collected sample are described herein. In certain embodiments, self-contained sample analysis systems are disclosed, which include a reusable reader component, a disposable cartridge component, and a disposable sample collection component. In some embodiments, the reader component communicates with a remote computing device for the digital transmission of test protocols and test results. In various disclosed embodiments, the systems, components, and methods are configured to identify the presence, absence, and/or quantity of particular nucleic acids, proteins, or other analytes of interest, for example, in order to test for the presence of one or more pathogens or contaminants in a sample.
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Citations
27 Claims
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1. A cartridge comprising:
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an input tunnel configured to permit full or partial insertion of a sample collection device adapted to be exposed to a sample; a sample reservoir configured to hold a fluid and configured to receive the sample from the sample collection device such that the sample and reagents mix in the fluid; a chemical substrate reservoir configured to hold a substrate solution comprising a chemical substrate, the chemical substrate reservoir fluidicly isolated from the sample reservoir; an analysis channel configured to receive, from the sample reservoir, the fluid comprising the sample and the reagents mixed therein, the analysis channel further configured to receive, from the chemical substrate reservoir, the substrate solution comprising the chemical substrate; and a sensor at least partially disposed within the analysis channel, the sensor configured to be exposed to the fluid comprising the sample and the reagents mixed therein from the sample reservoir in the analysis channel such that the reagents indicative of at least one of a presence, absence, or quantity of one or more analytes within the sample localize over the sensor, the sensor further configured to be exposed to the substrate solution comprising the chemical substrate from the chemical substrate reservoir such that the sensor generates an electrical signal indicative of at least one of the presence, absence, or quantity of the one or more analytes within the sample based on reactions between the chemical substrate and the reagents localized at the sensor within the analysis channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification