Non-reactive, hydrophilic polymers having terminal siloxanes and methods for making and using the same
First Claim
1. An ophthalmic device comprising a silicone-containing polymer and at least one stable, non-reactive hydrophilic polymer comprising in said non-reactive hydrophilic polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 500 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 20 siloxy units, wherein said non-reactive hydrophilic polymer is associated, via the linear silicone block, with said silicone-containing polymer and provides said ophthalmic device with a reduction in lipid uptake compared to the silicone-containing polymer of at least about 20%,wherein the at least one stable, non-reactive hydrophilic polymer is a polymer of Formula I:
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Abstract
The present invention relates to compositions comprising at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 10 to about 1000, and a linear silicone segment at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 200 siloxy units, and said non-reactive hydrophilic polymer is associated, via the linear silicone block with a silicone hydrogel. The non-reactive hydrophilic polymers may be incorporated into the formulation from which the silicone hydrogel is made or may be contacted with the silicone hydrogel post formation.
149 Citations
23 Claims
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1. An ophthalmic device comprising a silicone-containing polymer and at least one stable, non-reactive hydrophilic polymer comprising in said non-reactive hydrophilic polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 500 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 20 siloxy units, wherein said non-reactive hydrophilic polymer is associated, via the linear silicone block, with said silicone-containing polymer and provides said ophthalmic device with a reduction in lipid uptake compared to the silicone-containing polymer of at least about 20%,
wherein the at least one stable, non-reactive hydrophilic polymer is a polymer of Formula I:
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13. A process comprising contacting a silicone-containing contact lens with a solution comprising a contact angle lowering effective amount of at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said non-reactive hydrophilic polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 500 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 20 siloxy units, under contacting conditions suitable to associate said non-reactive hydrophilic polymer with said silicone-containing contact lens, wherein said non-reactive hydrophilic polymer is associated, via the linear silicone block, with said silicone-containing polymer and provides said ophthalmic device with a reduction in lipid uptake compared to the silicone-containing polymer of at least about 20%, and
wherein the at least one stable, non-reactive hydrophilic polymer is a polymer of Formula I:
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19. A process comprising
(a) Forming a reactive mixture comprising at least one silicone containing component, and at least one stable, near-monodisperse, non-reactive hydrophilic polymer comprising in said polymer'"'"'s backbone, a hydrophilic segment having a degree of polymerization of about 500 to about 10,000, and a linear silicone segment on at least one terminal end of said non-reactive hydrophilic polymer, wherein said silicone segment comprises between about 6 and about 20 siloxy units, wherein said non-reactive hydrophilic polymer is associated, via the linear silicone block, with said silicone-containing polymer and provides said ophthalmic device with a reduction in lipid uptake compared to the silicone-containing polymer of at least about 20%, and wherein the at least one stable, non-reactive hydrophilic polymer is a polymer of Formula I:
Specification