Method for providing a circuit for biological liquid and circuit obtained

• US 9,523,072 B2
• Filed: 03/08/2012
• Issued: 12/20/2016
• Est. Priority Date: 01/23/2009
• Status: Active Grant

• Current Assignee: EMD Millipore Corporation (Merck & Co., Inc.)
• Original Assignee: EMD Millipore Corporation (Merck & Co., Inc.)
• Inventors: Reinbigler, Rene, Weissenbach, Jean-Louis
• Primary Examiner(s): Mellon, David C
• Application Number:
  US13/414,843
• Publication Number:
  US 20120160356A1
• Time in Patent Office: 1,748 Days
• US Class Current: 1/1
• CPC Class Codes: A61L 2/0035 Gamma radiation
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/123 Flexible; Elastomeric
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 2400/0655 pinch valves
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B29C 2049/4805 by closing the mould halves
• CPC Class Codes: B29C 2049/4807 by movable mould parts in the mould halves
• CPC Class Codes: B29C 2949/08 Preforms made of several individual parts, e.g. by welding or gluing parts together
• CPC Class Codes: B29C 33/02 with incorporated heating or cooling means
• CPC Class Codes: B29C 49/0691 using sheet like material, e.g. sheet blow-moulding from joined sheets
• CPC Class Codes: B29C 49/06914 using parallel sheets as a preform
• CPC Class Codes: B29C 49/06916 Means for avoiding parts of the sheets to stick together, e.g. to provide blow opening
• CPC Class Codes: B29C 49/4815 by means of movable mould parts
• CPC Class Codes: B29C 65/02 by heating, with or without pressure
• CPC Class Codes: B29K 2023/0616 VLDPE, i.e. very low density polyethylene
• CPC Class Codes: B29K 2023/083 EVA, i.e. ethylene vinyl acetate copolymer
• CPC Class Codes: B29K 2023/086 : EVOH, i.e. ethylene vinyl alcohol copolymer
• CPC Class Codes: B29L 2009/00 : Layered products
• CPC Class Codes: B29L 2031/7148 : Blood bags, medical bags
• CPC Class Codes: C12M 23/14 : Bags
• CPC Class Codes: C12M 23/26 : flexible flexible containers for laboratory use B01L3/505
• CPC Class Codes: C12M 23/28 : disposable or single use
• CPC Class Codes: C12M 29/04 : Filters; Permeable or porous membranes or plates, e.g. dialysis
• CPC Class Codes: C12M 47/10 : Separation or concentration of fermentation products bioreactors combined with means for distillation or extraction of liquid fuel C12M43/02
• CPC Class Codes: Y10T 137/8593 : Systems
• CPC Class Codes: Y10T 137/9029 : With coupling

Abstract

A circuit for biological liquid including a bag having two films and a press. The press includes two shells that clamp the bag in a state in which pipes are formed between the films of the bag.

Claims

1. A circuit for biological liquid, comprising a plurality of connectors comprising routing network connectors and an inflating connector, and a network for routing liquid between said connectors, a disposable bag comprising two flexible films attached together by a seal delimiting a closed contour with said routing network connectors and inflating connector, said closed contour having an inside and an outside, said routing network connectors and inflating connector each opening respectively inside said closed contour and outside said closed contour;

and a press as two shells, said shells each comprising at least one recessed channel, and said press having a first open position during which said two flexible films of said disposable bag abut each other over their lengths and are devoid of pipes, and a second position where said press clamps said disposable bag in a state in which are formed, between said two flexible films of said disposable bag, pipes of said network for routing liquid, inflated by a pneumatic inflating agent injected into said disposable bag clamped between said shells, at least one said pipe having a contour of which at least one portion is delimited exclusively by cooperation with said press, and wherein said shells comprise a surface and a recessed channel recessed with respect to said surface for said at least one pipe having a contour of which at least one portion is delimited exclusively by cooperation with said press, wherein said injecting of said pneumatic inflating agent causes said pipes to each be formed into conformity with opposing recessed channels of the two shells to define said contour of which at least one portion is delimited exclusively by cooperation with said press.

2. A circuit according to claim 1, wherein each said recessed channel is of semi-circular cross-section.

3. A circuit according to claim 1, wherein each said recessed channel is bordered on each side by a groove in which is accommodated a respective bead of a network of beads serving to apply said films against one another along said pipes.

4. A circuit according to claim 1, wherein at least one said shell comprises means for welding said films along said pipes.

5. A circuit according to claim 1, further comprising at least one filter enclosed in said bag.

6. A circuit according to claim 1, wherein at least one said shell comprises at least one actuator of a pinch valve of one of said pipes.

7. A circuit according to claim 1, wherein at least one said shell comprises at least one sensor of a physico-chemical value.