Crosslinked fibers and method of making same using UV radiation

• US 9,523,159 B2
• Filed: 02/22/2010
• Issued: 12/20/2016
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc), Sofradim Production
• Inventors: Hadba, Ahmad Robert, Ladet, Sbastien
• Primary Examiner(s): YOUNG, MICAH PAUL
• Application Number:
  US13/202,388
• Publication Number:
  US 20120021015A1
• Time in Patent Office: 2,493 Days
• Field of Search: 424/400, 525/407, 525/43, 525/56, 526/265, 526/287, 526/310, 526/347
• US Class Current: 1/1
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08G 75/045 from mercapto compounds and unsaturated compounds
• CPC Class Codes: D01D 10/00 Physical treatment of artificial filaments or the like during manufacture, i.e. during a continuous production process before the filaments have been collected finishing D02J
• CPC Class Codes: D01F 6/78 from copolycondensation products
• CPC Class Codes: D01F 6/86 from polyetheresters
• CPC Class Codes: D10B 2331/30 polycondensation products not covered by indexing codes D10B2331/02 - D10B2331/14
• CPC Class Codes: D10B 2509/00 Medical; Hygiene

Abstract

Cross-linked fibers include first and second precursors, each possessing a core and at least one functional group known to have click reactivity when exposed to UV radiation. Mixtures of the first and second precursors are extruded to produce a filament and irradiated with UV light during the extrusion process.

Claims

1. A process of forming a cross-linked filament for a surgical device comprising:

mixing first and second precursors, each of the first and second precursors possessing a polyol core and functionalized with at least one functional group having click reactivity when exposed to UV radiation, wherein the at least one functional group of the first precursor is a thiol group and the at least one functional group of the second precursor is an alkene group; and

extruding the first and second precursors through an extrusion unit to produce a filament,

exposing the first and second precursors to UV radiation during the extruding process.

2. The process of claim 1, wherein the polyol core of the first precursor is selected from the group consisting of polyethers, polyesters, polyether-esters, polyalkanols, and combinations thereof.

3. The process of claim 1, wherein the polyol core of the second precursor is selected from the group consisting of polyethers, polyesters, polyether-esters, polyalkanols, and combinations thereof.

4. The process according to claim 1, wherein exposing the first and second precursors to UV radiation occurs while in a molten state.

5. The process according to claim 1, wherein exposing the first and second precursors to UV radiation occurs after forming the filament.

6. The process according to claim 1, wherein exposing the first and second precursors to UV radiation further comprises passing the filament through a quench bath irradiated with a UV light.

7. The process according to claim 1, wherein the polyol core of the first precursor comprises a poly(ethylene glycol) with a molecular weight from about 200 g/mol to about 10000 g/mol.

8. The process according to claim 1, wherein the polyol core of the first precursor comprises a poly(ethylene glycol) with a molecular weight from about 400 g/mol to about 900 g/mol.

9. The process according to claim 1, wherein the polyol core of the second precursor comprises a poly(ethylene glycol) with a molecular weight from about 200 g/mol to about 10000 g/mol.

10. The process according to claim 1, wherein the polyol core of the second precursor comprises a poly(ethylene glycol) with a molecular weight from about 400 g/mol to about 900 g/mol.

11. The process according to claim 1, wherein the polyol core of the first precursor and the polyol core of the second precursor are different.

12. The process according to claim 1, wherein the at least one functional group of the first precursor and the at least one functional group of the second precursor are present in a ratio of about 1:

2 to 1;

1.