Medical use of a DPP-4 inhibitor

• US 9,526,728 B2
• Filed: 02/27/2015
• Issued: 12/27/2016
• Est. Priority Date: 02/28/2014
• Status: Active Grant

• Current Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim International GmbH (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Klein, Thomas, Advani, Andrew, Connelly, Kim Alexander, Gilbert, Richard Ernest
• Primary Examiner(s): Murray, Jeffrey H
• Application Number:
  US14/633,489
• Publication Number:
  US 20150246045A1
• Time in Patent Office: 669 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/4439 containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole nicotine A61K31/465
• CPC Class Codes: A61K 31/4985 Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/64 Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Abstract

The present invention relates to the use of 1-[(4-methyl-quinazolin-2-yl)methyl]-3 -methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine for use in a patient being at risk of or having heart failure with preserved ejection fraction (HFpEF).

Claims

1. A method for treating a patient being at risk of or having heart failure with preserved ejection fraction (HFpEF), the method comprising administering to the patient 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine, optionally in combination with one or more other active agents.

2. The method of claim 1, wherein the patient has chronic kidney disease (CKD).

3. The method of claim 1, wherein the patient has severe renal impairment or end-stage renal disease (ESRD).

4. The method of claim 1, said method further comprising treating, reducing the risk of, slowing progression of, delaying the onset of, and/or protecting against heart failure with preserved ejection fraction (HFpEF) and/or diseases associated therewith.

5. The method of claim 4, wherein the disease associated with HFpEF is a major adverse cardiovascular event (MACE) selected from the group consisting of myocardial infarction, stroke, cardiovascular death, and cardiovascular hospitalization for unstable or stable angina pectoris, heart failure and coronary revascularization.

6. The method of claim 1, said method further comprising treating, reducing the risk of, slowing progression of, delaying the onset of, and/or protecting against diastolic dysfunction and/or cardiac fibrosis.

7. The method of claim 1, wherein the patient is a diabetic patient.

8. The method of claim 1, wherein the patient is a non-diabetic patient.