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Solvent/polymer solutions as suspension vehicles

  • US 9,526,763 B2
  • Filed: 06/24/2015
  • Issued: 12/27/2016
  • Est. Priority Date: 02/03/2005
  • Status: Active Grant
First Claim
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1. A stable, nonaqueous suspension formulation, comprising:

  • a particle formulation comprising an active agent and at least one excipient, wherein;

    the active agent comprises at least one of a peptide, a polypeptide, and a protein; and

    the at least one excipient comprises methionine; and

    a nonaqueous, single-phase vehicle consisting essentially of about 10% (w/w) to about 90% (w/w) polymer and about 90% (w/w) to about 10% (w/w) solvent, wherein;

    the polymer is at least one of a polyester, a pyrrolidone, an ester of an unsaturated alcohol, an ether of an unsaturated alcohol, and a polyoxyethylenepolyoxypropylene block copolymer;

    the solvent is at least one of lauryl alcohol, lauryl lactate, benzyl benzoate, benzyl alcohol, decanol, and ethyl hexyl lactate; and

    the vehicle has a viscosity of about 1,000 poise to about 100,000 poise.

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