Electrode designs for efficient neural stimulation

• US 9,526,890 B2
• Filed: 04/10/2015
• Issued: 12/27/2016
• Est. Priority Date: 10/11/2012
• Status: Active Grant

• Current Assignee: Sunnybrook Research Institute
• Original Assignee: Sunnybrook Research Institute
• Inventors: Golestanirad, Laleh, Graham, Simon J.
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US14/683,323
• Publication Number:
  US 20150209577A1
• Time in Patent Office: 627 Days
• US Class Current: 1/1
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0565 Electrode heads
• CPC Class Codes: A61N 1/0587 Epicardial electrode systems; Endocardial electrodes piercing the pericardium

Abstract

Electrodes for use in neural stimulation applications, shaped to have fractal or pseudo-fractal geometries, with a generally planar core portion of the electrode using a base fractal geometry. A series of successively smaller holes is provided in the core portion, where each hole in the generally planar core portion can have a perimeter shape that is self-similar to a perimeter shape of the generally planar core portion. The selected electrode geometry affects the spatial distribution of the electric field in neuron-bearing tissue. This spatial distribution is related to the irregularity—or non-uniformity—of current density on the electrode surface. Optimized electrode geometries increase the efficiency of neural stimulation by maximizing the spatial variation of current density on the electrode surface.

Claims

1. An electrode for neural stimulation, the electrode comprising:

an electrically conductive body, the body having a generally planar core portion,

wherein the generally planar core portion has a plurality of holes therein, and wherein the plurality of holes has one or more internal perimeters,

wherein each of the one or more internal perimeters comprises at least three edges and at least three vertices, each edge being joined to its adjacent edges at a respective one of the at least three vertices,

wherein a shape of the generally planar core portion is obtainable from a base shape that corresponds to a regular polygon having n sides by;

removing a first order smaller regular polygon having n sides from the interior of the base shape to provide a first order hole in the plurality of holes, the first order hole having n edges,

dividing an area of the first order smaller regular polygon into a plurality of second order smaller regular polygons having n sides, and

increasing a number of vertices of the shape by attaching the second order smaller regular polygons to one or more selected edges of the shape.

2. The electrode of claim 1, wherein the at least three edges define a non-180°

angle at each vertex in the at least three vertices.

3. The electrode of claim 1, wherein respective edges and vertices of the plurality of holes are configured to reduce a capacity dimension of a surface of the core portion to less than 2.

4. The electrode of claim 1, wherein each of the one or more internal perimeters comprise at least twelve edges and at least twelve vertices.

5. The electrode of claim 4, wherein the plurality of holes form a Sierpinski triangle of at least order 2.

6. The electrode of claim 1, wherein each of the one or more internal perimeters comprise at least thirty-six edges and at least thirty-six vertices.

7. The electrode of claim 6, wherein the plurality of holes form a Sierpinski square of at least order 2.

8. The electrode of claim 1, wherein each of the plurality of holes has a perimeter shape that is self-similar to a perimeter shape of the generally planar core portion.

9. The electrode of claim 1, wherein the generally planar core portion has a base shape that corresponds to a regular polygon having n sides.

10. The electrode of claim 1, wherein the shape is further obtainable by removing a plurality of k-th order smaller regular polygons having n sides from the interior of the base shape to provide a plurality of k-th order holes in the plurality of holes, each of the plurality of k-th order holes having n edges.

11. The electrode of claim 10, wherein the shape is further obtainable by repeatedly removing the plurality of k-th order smaller regular polygons for two or more integer values of k.

12. The electrode of claim 10, wherein the shape is further obtainable by dividing an area of each of the plurality of k-th order smaller regular polygons to provide (k+1)-th order smaller regular polygons having n sides, and attaching the (k+1)-th order smaller regular polygons to an edge of the shape.

13. The electrode of claim 10, wherein k is between 2 and 5.

14. The electrode of claim 1, wherein n is at least 20, and wherein the generally planar core portion approximates a closed curve in shape.

15. The electrode of claim 1, wherein the generally planar core portion forms a closed curve in shape, and wherein each of the plurality of holes forms a closed curve in shape.

16. The electrode of claim 1, wherein a shape of the generally planar core portion is obtainable from a base shape that corresponds to a closed curve by removing a first order smaller closed curve from the interior of the base shape to provide a first order hole in the plurality of holes.

17. The electrode of claim 16, wherein the shape is further obtainable by removing a plurality of k-th order smaller closed curves from the interior of the base shape to provide a plurality of k-th order holes in the plurality of holes.

18. The electrode of claim 17, wherein the shape is further obtainable by repeatedly removing the plurality of k-th order smaller closed curves for two or more integer values of k.

19. The electrode of claim 1, wherein the generally planar core portion is curved.

20. The electrode of claim 1, wherein the generally planar core portion is flexible.

21. The electrode of claim 1, wherein the one or more selected edges of the shape comprise at least one external perimeter edge of the generally planar core portion, and wherein attaching the second order smaller regular polygons to one or more selected edges of the shape.

22. The electrode of claim 1, wherein the one or more selected edges of the shape comprise at least one of the at least three edges of the one or more internal perimeters.