Implantable neurostimulator for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration
First Claim
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1. A vagus nerve neurostimulator for treatment of chronic cardiac dysfunction, comprising:
- a pulse generator, wherein the pulse generator generates a pulsed electrical signal comprising;
a signal ON time;
a signal OFF time;
an output current;
a signal frequency;
a pulse width; and
a duty cycle defined by dividing the signal ON time by the sum of the signal ON time and signal OFF time;
a therapy lead;
an electrode communicatively coupled to the pulse generator via the therapy lead; and
a recordable memory storing a maximum stimulation intensity and an autotitration operating mode configured to cause the pulse generator to increase an intensity of the pulsed electrical signal up to a level not exceeding the maximum stimulation intensity and to receive, from a patient-operable external controller that allows the patient to provide feedback regarding whether the intensity is intolerable, a first unique signal indicating that the intensity of the delivered pulsed electrical signal is not tolerable to the patient.
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Abstract
A system for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration is provided. The system includes a patient-operable external controller to transmit a plurality of unique signals. The system further includes an implantable neurostimulator, which includes a recordable memory storing an autotitration operating mode that includes a maximum stimulation intensity and is configured to increase an intensity of the delivered electrical therapeutic stimulation up to a level not exceeding the maximum stimulation intensity upon receipt of one of the unique signals.
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Citations
20 Claims
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1. A vagus nerve neurostimulator for treatment of chronic cardiac dysfunction, comprising:
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a pulse generator, wherein the pulse generator generates a pulsed electrical signal comprising; a signal ON time; a signal OFF time; an output current; a signal frequency; a pulse width; and a duty cycle defined by dividing the signal ON time by the sum of the signal ON time and signal OFF time; a therapy lead; an electrode communicatively coupled to the pulse generator via the therapy lead; and a recordable memory storing a maximum stimulation intensity and an autotitration operating mode configured to cause the pulse generator to increase an intensity of the pulsed electrical signal up to a level not exceeding the maximum stimulation intensity and to receive, from a patient-operable external controller that allows the patient to provide feedback regarding whether the intensity is intolerable, a first unique signal indicating that the intensity of the delivered pulsed electrical signal is not tolerable to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of operating a vagus nerve neurostimulator to treat chronic cardiac dysfunction, comprising:
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delivering a pulsed electrical signal to a vagus nerve via an electrode coupled to a pulse generator via a therapy lead, the pulsed electrical signal comprising;
a signal ON time;
a signal OFF time;
an output current;
a signal frequency;
a pulse width; and
a duty cycle defined by dividing the signal ON time by the sum of the signal ON time and signal OFF time;operating the pulse generator in an autotitration operating mode, the autotitration operating mode comprising increasing an intensity of the pulsed electrical signal up to a level not exceeding a maximum stimulation intensity stored in a recordable memory; and receiving, from a patient-operable external controller that allows the patient to provide feedback regarding whether the intensity is intolerable, a first unique signal indicating that the intensity of the delivered pulsed electrical signal is not tolerable to the patient. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification