Stable crystal form of tipiracil hydrochloride and crystallization method for the same
DCFirst Claim
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1. A crystal of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, which is crystal Form I, exhibiting peaks at two or more angles selected from the group consisting of 11.6°
- , 17.2°
, 17.8°
, 23.3°
, 27.1°
, and 29.3°
as a diffraction angle (2θ
±
0.1°
) in powder X-ray diffraction.
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Abstract
An objective of the present invention is to obtain a stable crystal form of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride. The present invention provides a crystal of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride exhibiting characteristic peaks at angles of 11.6°, 17.2°, 17.8°, 23.3°, 27.1°, and 29.3° as a diffraction angle (2θ±0.1°) in powder X-ray diffraction.
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9 Claims
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1. A crystal of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride, which is crystal Form I, exhibiting peaks at two or more angles selected from the group consisting of 11.6°
- , 17.2°
, 17.8°
, 23.3°
, 27.1°
, and 29.3°
as a diffraction angle (2θ
±
0.1°
) in powder X-ray diffraction. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- , 17.2°
Specification