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Optimization of nucleation and crystallization for lyophilization using gap freezing

  • US 9,528,761 B2
  • Filed: 04/20/2015
  • Issued: 12/27/2016
  • Est. Priority Date: 09/28/2010
  • Status: Active Grant
First Claim
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1. A method comprising:

  • loading containers comprising a liquid solution on to a plurality of trays comprising tray surfaces in a lyophilization chamber, the tray surfaces being disposed between parallel upper and lower heat sinks, wherein the trays are optionally thermal conductors and wherein the liquid solution comprises a solute and a solvent;

    providing a thermal conduction insulator forming a fixed distance from the container on the tray to the respective lower heat sink surface; and

    lowering the temperature of the heat sinks and thereby the ambient temperature in the lyophilization chamber comprising the containers, tray surfaces and thermal insulators to a temperature sufficient to freeze the liquid solution and form a frozen solution.

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