Method and apparatus for determining analyte concentration by quantifying and interpreting color information captured in a continuous or periodic manner
First Claim
1. A method comprising:
- applying a biological sample to a plurality of test pads of a test paddle;
capturing images over periods of time of the plurality of test pads of the test paddle as different reagents of the test pads react to the biological sample;
quantifying each color of the plurality of test pads in each of the captured images over time;
determining a color trajectory over time for each test pad of the plurality of test pads;
comparing the color trajectory with calibration curves to determine analyte concentration for one or more of the plurality of test pads; and
displaying results of the analyte concentration to a user in response to the comparison.
4 Assignments
0 Petitions
Accused Products
Abstract
In one embodiment, an apparatus for automatic test diagnosis of a test paddle is disclosed. The apparatus comprises a personal computing device including: a camera to capture images over time of test pads of a test paddle, a processor coupled to the camera, and a display device coupled to the processor. The processor analyzes the color changes over time of each test pad to determine a color trajectory over time for each test pad. The processor compares the color evolution trajectory for each test pad with color calibration curves for each test pad to determine an analyte concentration of a test biological sample, such as urine. During the analysis by the processor, the display device displays a user interface with results of the analyte concentration in response to the analysis over time.
87 Citations
21 Claims
-
1. A method comprising:
-
applying a biological sample to a plurality of test pads of a test paddle; capturing images over periods of time of the plurality of test pads of the test paddle as different reagents of the test pads react to the biological sample; quantifying each color of the plurality of test pads in each of the captured images over time; determining a color trajectory over time for each test pad of the plurality of test pads; comparing the color trajectory with calibration curves to determine analyte concentration for one or more of the plurality of test pads; and displaying results of the analyte concentration to a user in response to the comparison. - View Dependent Claims (2, 3, 4)
-
-
5. An apparatus for automatic test diagnosis of a biological sample with a test paddle, the apparatus comprising:
a personal computing device including; a camera to capture images over time of test pads of a test paddle; a processor coupled to the camera, the processor to analyze color over time of each test pad; determine a color trajectory over time for each test pad; compare the color trajectory for each test pad with associated color calibration curves for each test pad to determine analyte concentrations in a biological sample; and a display device coupled to the processor, the display device to display results of the analyte concentrations to a user in response the comparison. - View Dependent Claims (6, 7, 8, 9)
-
10. A method comprising:
-
(a) applying a known concentration of an analyte in a biological sample of a predetermined acidity to a test pad at a predetermined temperature; (b) capturing color images over a plurality time points of the test pad as it reacts to the biological sample; (c) quantifying a color of the test pad in each of the captured color images at each of the plurality of time points; repeating steps (a) through (c) for a plurality of differing concentrations of the analyte in a plurality of biological samples for one or more test pads; and plotting along a curve in three dimensions of color space coordinates of a color graph, the quantified color for each respective time point for the plurality of concentrations of analyte to form a plurality of color calibration curves respectively associated with the plurality of time points. - View Dependent Claims (11, 12, 13, 14)
-
-
15. A method comprising:
-
applying a biological sample with an unknown concentration of analyte to a test pad; capturing color images of the test pad at measured time points as it reacts to the unknown concentration of analyte in the biological sample; quantifying each color of the test pad in each of the captured color images at each measured time point from a first measured time point to a last measured time point; and determining a concentration of an analyte in the measured biological sample in response to one or more quantified colors of the test pad at one or more measured time points. - View Dependent Claims (16, 17, 18, 19, 20, 21)
-
Specification